雷米普利联合氨氯地平对原发性高血压患者左心室肥厚及尿微量白蛋白的影响

目的探讨雷米普利联合氨氯地平对原发性高血压病（EH）患者收缩压（SBP）、舒张压（DBP）、左心室肥厚（LVH）及尿微量白蛋白（mALB）的影响。方法将99例伴有LVH和尿mALB的EH患者随机分为A、B、C三组,每组各有33例。A组给予雷米普利5～10mg,每天1次;B组给予氨氯地平5～10mg,每天1次;C组联合使用雷米普利和氨氯地平,剂量同上,疗程24周。分别在用药前、用药24周末测量患者SBP和DBP及尿mALB含量,同时应用超声心动图检查评价LVH指标。结果三组治疗24周后SBP、DBP、LVH指标、尿mALB改变与用药前比较差异有统计学意义（P〈0.05）。组间比较C组明显优于A、B组（P〈0.01）。结论雷米普利联合氨氯地平较单药更能有效平稳地控制高血压,且能逆转LVH,降低尿mALB,保护心、肾功能。

Effect of ramipril combined with amlodipine in left ventricular hypertrophy and urinary mALB in essential hypertension (EH)patients

Aim To study the effects of ramipril and amlodipine in systolic blood pressure(SBP),diastolic blood pressure(DBP),left ventricular hypertrophy(LVH)and urinary mALB in essential hypertension(EH)Patients.Methods 99 cases of EH patients with LVH and urinary mALB were chosen and randomly divided into three groups-A,B and C,33 cases per group.The patients of A were administered ramipril 5 to 10 mg,once per day,the patients of B amlodipine 5 to 10 mg,once per day;the patients of C ramipril and amlodipine dose same as above.Time of therapy is 24 weeks.Before and after the therapeutic period,we measure SBP,DBP,urinary mALB of EH patients,and at the same time,evaluate LVH index.Results After treatment for 24 weeks,SBP,DBP,urinary mALB and LVH are significantly different(P<0.01)index compared with pre-treatment.Group C surpass obviously group A and group B in group comparison(P<0.01).Conclusion Ramipril combined with amlodipine can more placidly control EH compard with the single medicine,and they can reverse LVH,depress urinary mALB,protect heart and renal function.