| MSCT灌注成像评价兔积水肾肾功能的可复性 |
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| 引用本文： | 贾鸿飞,亓卿燕,武志峰,许志高,郝新忠. MSCT灌注成像评价兔积水肾肾功能的可复性[J]. 中国医学影像技术, 2010, 26(5): 805-808 |
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| 作者姓名： | 贾鸿飞 亓卿燕 武志峰 许志高 郝新忠 |
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| 作者单位： | 1. 大同市第二人民医院放射科,山西,大同,037005
2. 山西医科大学第一附属医院CT室,山西,太原,030001 |
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| 摘 要： | 目的 探讨MSCT灌注成像对积水肾肾功能可复性的预测价值.方法 48只雄性新西兰大白兔随机分为1周组、3周组、5周组和7周组(每组n=12),每组再随机分为假手术组(Sham,n=6)和梗阻组(Ob,n=6).梗阻组通过手术制成输尿管完全梗阻及积水肾模型,假手术组施行同样手术,但不结扎输尿管.分别于术前及各自的梗阻时间点接受MSCT灌注扫描和SPECT检查,测定左肾皮质的血流量(BF)、血容量(BV)、达峰时间(TTP)和肾小球率过滤(GRF).解除梗阻2个月后再次复查.各阶段分别处死1只动物行病理学观察.结果 ①MSCT灌注扫描:不同时间段,假手术组术前、术后BF、BV、TTP值比较差异无统计学意义(P>0.05).梗阻后,随梗阻时间延长,BF、BV值逐渐降低,4组间梗阻解除前BF、BV值比较,差异均有统计学意义(P<0.05).梗阻解除后,梗阻1周组BF、BV值恢复到接近术前水平(P>0.05);梗阻3周组BF、BV值与术前比较差异有统计学意义(P<0.05),与解除前比较差异无统计学意义(P>0.05);梗阻5周组及梗阻7周组BF、BV值持续降低,与梗阻解除前、术前比较,差异均有统计学意义(P<0.05).梗阻后,梗阻1、3、5周组TTP值随梗阻时间延长而逐渐延长(P<0.05),梗阻5周组与7周组间比较及各自与解除后比较均无变化(P均>0.05).②SPECT肾动态显像:不同时间段,假手术组术前、术后GRF值比较差异无统计学意义(P>0.05).假手术组及梗阻组术前、梗阻解除前及梗阻解除后各组GRF值比较,差异无统计学意义(P>0.05).梗阻解除前1、3、5及7周组间GRF值比较,差异均有统计学意义(P<0.05).③病理学结果:随梗阻时间延长,肾小管扩张越明显,肾纤维化程度逐渐渐加重.结论 单侧输尿管完全梗阻后,积水肾皮质BF、BV值分别下降志(312.21±26.35)ml/(100 g·min)、(10.76±5.37)ml/(100 g)时,肾功能难以恢复到正常水平.MSCT灌注成像能为术前肾功能恢复潜力评价提供有价值信息.
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| 关 键 词： | 灌注成像 肾盂积水 肾功能试验 体层摄影术,X线计算机 动物实验 |
| 收稿时间： | 2009-12-20 |
| 修稿时间： | 2010-01-21 |
MSCT perfusion imaging in evaluation of restorability of rabbits renal function of hydronephrotic kidney |
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| JIA Hong-fei,QI Qing-yan,WU Zhi-feng,XU Zhi-gao and HAO Xin-zhong. MSCT perfusion imaging in evaluation of restorability of rabbits renal function of hydronephrotic kidney[J]. Chinese Journal of Medical Imaging Technology, 2010, 26(5): 805-808 |
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| Authors: | JIA Hong-fei QI Qing-yan WU Zhi-feng XU Zhi-gao HAO Xin-zhong |
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| Affiliation: | Department of Radiology, the Second People's Hospital of Datong, Datong 037005, China;CT Room, the First Hospital of Shanxi Medical University, Taiyuan 030001, China;CT Room, the First Hospital of Shanxi Medical University, Taiyuan 030001, China;CT Room, the First Hospital of Shanxi Medical University, Taiyuan 030001, China;CT Room, the First Hospital of Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Objective To assess the value of MSCT perfusion in the restorability of renal function of hydronephrotic kidney due to completed unbilateral uterus obstruction. Methods Forty-eight healthy adult male rabbits were randomly divided into 4 groups as 1 week group,3 weeks group,5 weeks group and 7 weeks group (1 w,3 w,5 w,7 w,each n=10). Then rabbits in every group were randomly divided into sham-operated subgroup and obstruction subgroup. Rabbits in obstruction subgroups were operated as complete ureteral obstr... |
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| Keywords: | Perfusion imaging Hydronephrosis Kidney function tests Tomography, X-ray computed Animal experimentation |
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