冠状动脉粥样硬化斑块磁共振成像研究进展

当前直接显示冠状动脉管壁和粥样斑块为磁共振成像(MRI)研究的热点之一,这是因为不引起冠状动脉管腔50%以上狭窄程度的粥样硬化斑块常为具有破裂倾向的易损斑块,斑块破裂随后血栓形成是导致心肌梗死的主要原因。无创性、高分辨率MRI具有显示冠状动脉粥样硬化斑块、判定斑块成分的潜力。本综述总结冠脉斑块MR成像原理,描述现有MRI技术下斑块的信号特点,并讨论MR在斑块成像的新对比剂、靶向分子成像等方面的研究进展。

Advances of MR imaging in coronary atherosclerosis plaque

Current coronary MR imaging technical developments focus on direct visualization of the diseased coronary vessel wall and imaging of coronary plaque, because plaques without stenosis are typically more vulnerable with higher risk of plaque rupture. Plaque rupture with subsequent thrombosis and vessel occlusion is the main cause of myocardial infarction. Non-invasive, high-resolution MR has the potential to image coronary plaque and to determine its composition and microanatomy. This review summarizes the rationale for coronary plaque imaging, and describes the characteristics of plaque using existing MRI techniques. Current and future applications of MRI, including the development of new contrast agents, and targeted molecular imaging.