| 通脉养心丸对实验性心律失常的保护作用 |
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| 引用本文： | 蔡小军,王怡,胡利民.通脉养心丸对实验性心律失常的保护作用[J].世界中医药,2010,5(6):425-426. |
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| 作者姓名： | 蔡小军 王怡 胡利民 |
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| 作者单位： | 天津中医药大学中医药研究院药理毒理部,天津市南开区鞍山西道玉泉路88号300193 |
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| 摘 要： | 目的：观察通脉养心丸对实验性心律失常的保护作用。方法：采用氯仿致小鼠心律失常及氯化钡（BaCl2）致大鼠心律失常模型，观察通脉养心丸对氯仿致小鼠心脏停搏（CA）的潜伏期（min）、室颤发生率（％）及BaCl2致大鼠心律失常持续时间（min）的影响。结果：通脉养心丸可明显降低氯仿所致小鼠的室颤发生率，延长CA的潜伏期，显著缩短BaCl2所致心律失常的持续时间，且4．0g／kg剂量组作用明显优于2．0g／kg、1．0g／kg剂量组。结论：通脉养心丸对实验性心律失常具有保护作用。
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| 关 键 词： | 心律失常 中医药疗法 通脉养心丸 室颤发生率 |
| 收稿时间： | 2009/4/13 0:00:00 |
Protection of Tongmai Yangxin Pill on Arrhythmia on Animal Models |
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| Cai Xiaojun,Wang Yi,Hu Limin.Protection of Tongmai Yangxin Pill on Arrhythmia on Animal Models[J].World Chinese Medicine,2010,5(6):425-426. |
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| Authors: | Cai Xiaojun Wang Yi Hu Limin |
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| Institution: | (Dept. of Pharmacology, TCM Institute, Tianjin University of Chinese Medicine, Add. ： No. 88, Yuquan Road, Anshan West Road, Nankai District, Tianjin , Post code ： 300193 ) |
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| Abstract: | Objective：To observe protection of Tongmai Yangxin Pill on arrhythmia on animal models. Methods：The models were established on mice and rats respectively by chloroform and BaCl2 , and given Tongmai Yangxin Pill, then observed latent time of heart arrest and fibrillation ventricular on mice model, and duration of arrhythmia on rats model. Results： Tongmai Yangxin Pill can significantly reduce fibrillation ventricular incidence, prolong CA latent period, shorten duration of BaCl2 induced arrhythmia, in particular the dosage of 4.0g/kg was preferable to 2.0 g/kg and 1.0 g/kg. Conclusion：Tongmai Yangxin Pill has good protective effect on arrhythmia on animal models. |
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| Keywords: | Arrhythmia/ Chinese medical therapy @ Tongmai Yangxin Pill |
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