单纯疱疹病毒性角膜炎中细胞凋亡的作用机制研究进展

单纯疱疹病毒性角膜炎（HSK）是一种严重的世界性致盲性角膜疾病,发病机制目前尚不明确。近年来的研究表明,该病的发病机制与细胞凋亡密切相关。病毒感染角膜后,可诱导角膜上皮细胞发生凋亡,随后抑制凋亡过程。同时亦可引起浅层基质发生细胞凋亡,以防止病毒从感染的上皮细胞传染至角膜深部。而当病变累及角膜深层时,常可发生角膜基质混浊、坏死、瘢痕形成、新生血管化以及角膜内皮皱褶等。就HSK发病过程中角膜上皮、基质、内皮发生细胞凋亡的机制进行综述。

Research advances in mechanism of apoptosis in herpes simplex keratitis

Herpes simplex keratitis （HSK） is a serious and worldwide blinding corneal diseases. The pathogenesis is unclear now. In recent years,studies have shown that it is closely related with apoptosis. After corneal infection,corneal epithelial cells can be induced to apoptosis, following that, the apoptosis is inhibited. Immediately after epithelial insult, corneal stromal underlying the lesion of injury undergo apoptosis to retard extension of the virus into the deeper cornea. Following this event, corneal stroma sequcntialy occurs change at many patterns, including turbid, necrosis, scar formation, neovascularization, corneal endothelial cell reduce and so on. This review reveales the latest advances in the mechanism of apoptosis in corneal epithelium, stroma,endothelial ceils in the course of HSK.