| 慢性乙型肝炎和肝硬化患者血清可溶性细胞间粘附分子-1的检测 |
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| 引用本文： | 尹洪竹,刘金星,汤慧华,曹治宸,李兵顺,冯忠军. 慢性乙型肝炎和肝硬化患者血清可溶性细胞间粘附分子-1的检测[J]. 实用肝脏病杂志, 1999, 0(4) |
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| 作者姓名： | 尹洪竹 刘金星 汤慧华 曹治宸 李兵顺 冯忠军 |
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| 作者单位： | 河北医科大学第三医院传染科，河北医科大学第三医院传染科，第三医院中心化验室，石家庄市 河北医科大学第三医院传染科，石家庄市 河北医科大学第三医院传染科，第三医院中心化验室 050051 石家庄市，050051 石家庄市，050051，050051 |
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| 摘 要： | 目的 探讨可溶性细胞间粘附分子-1(sICAM-1)在慢性乙型肝炎和肝硬化中的临床意义。方法 应用酶联免疫吸附法检测56例慢性乙型肝炎和18例肝硬化患者血清sICAM-1水平,并同时检测肝功能和T细胞亚群。结果 慢性乙型肝炎和肝硬化患者血清sICAM-1水平明显高于正常人(P<0.01/0.05),且随着肝细胞损伤程度的加重而升高,与T细胞亚群无相关性。结论 血清sICAM-1水平可反映慢性乙型肝炎患者的肝细胞坏死程度。
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| 关 键 词： | 可溶性细胞间粘附分子-1 慢性乙型肝炎 肝硬化 |
THE SERUM LEVEL OF SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 IN PATIENTS WITH CHRONIC HEPATITIS B AND LIVER CIRRHOSIS |
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| Yin Hongzhu,Liu Jinxing,Tang huihua,et al.. THE SERUM LEVEL OF SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 IN PATIENTS WITH CHRONIC HEPATITIS B AND LIVER CIRRHOSIS[J]. Journal of Clinical Hepatology, 1999, 0(4) |
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| Authors: | Yin Hongzhu Liu Jinxing Tang huihua et al. |
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| Affiliation: | Yin Hongzhu,Liu Jinxing,Tang huihua,et al. Departemt of Infectious Diseases,The Third Hospital of Hebei Medical University,Shijiazhuang 050051 |
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| Abstract: | Objective To detect the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with chronic hepatits B and with liver cirrhosis. Methods Serum sICAM-1 was detected by ELISA and the liver function and T lymphocyte subsets were detected in 56 patients with chronic hepatitis B and 18 with liver cirrhosis. Results Serum sICAM-1 level in chronic hepatitis B and liver cirrhosis were obviously higher than in normal control ( P >0.01/0.05) and peralleled with the liver function damage, while there was no correlation to CD4+ ,CD8+ or the ratio of CD4+ /CD8+ . Conclusion Serum sICAM-1 levels increase in chronic hepatitis B and in liver cirrhosis. |
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| Keywords: | Soluble Intercellular Adhesion Molecule-1 Liver Cirrhosis Hepatitis B |
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