INCREASED EXPRESSION OF INTERFERON (IFN)-GAMMA TOGETHER WITH IFN-GAMMA RECEPTOR IN THE RHEUMATOID SYNOVIAL MEMBRANE COMPARED WITH SYNOVIUM OF PATIENTS WITH OSTEOARTHRITIS |
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| Authors: | DOLHAIN, R. J. E. M. HAAR, N. T. TER HOEFAKKER, S. TAK, P. P. LEY, M. DE CLAASSEN, E. BREEDVELD, F. C. MILTENBURG, A. M. M. |
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| Affiliation: | *Department of Rheumatology, University Hospital Leiden
!["{dagger}"]("/math/dagger.gif") TNO Prevention and Health Leiden
!["{ddagger}"]("/math/Dagger.gif") Department of General Internal Medicine, University Hospital Leiden Leiden, The Netherlands
!["§"]("/math/sect.gif") Laboratory for Biochemistry, Leuven University Leuven, Belgium |
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| Abstract: | Data concerning the presence of T-cell-derived cytokines inthe rheumatic joint are conflicting, challenging, the hypothesisthat rheumatoid arthritis (RA) is a T-cell-mediated disease.In this study synovial tissue specimens of 11 patients withRA and eight patients with osteoarthritis (OA) were stainedfor interferon-gamma (IFN- |
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