卵巢癌患者应对方式与生活质量的关系:恐惧疾病进展的中介作用

目的 探讨卵巢癌患者应对方式、恐惧疾病进展与生活质量之间的关系。方法 采用医学应对方式问卷、恐惧疾病进展简化量表及癌症治疗功能评价量表对279例卵巢癌患者进行横断面调查。结果 卵巢癌患者面对、回避、恐惧疾病进展、生活质量总分分别为(18.27±4.47)分、(16.32±3.97)分、(35.07±5.72)分、(70.82±11.25)分，且4个变量之间均显著相关(r = - 0.555～0.483, P＜0.05)。面对和回避应对方式既可以直接预测恐惧疾病进展(β = -0.207, β = 0.396, P＜0.05)，又可以直接和通过恐惧疾病进展间接预测生活质量(β = 0.184, β = - 0.339, β = 0.074, β = - 0.142, P＜0.05)，中介效应分别占总效应的28.68%和29.52%。结论 恐惧疾病进展是卵巢癌患者应对方式影响生活质量的重要中间环节。

Coping style and quality of life of ovarian cancer patients: the moderating role of fear of progression

Objective To investigate the relationship among coping styles,fear of progression, and quality of life among ovarian cancer patients. Methods A cross-sectional survey of 279 patients with ovarian cancer was conducted. The instruments included confrontation coping style and avoidance coping style of Medical Coping Mode Questionnaire, Fear of Progression Questionnaire-Short Form and the Functional Assessment of Cancer Therapy-Genera. Results The total score of patients’ confrontation coping style, avoidance coping style, fear of progression and quality of life were(18.27 ±4.47),(16.32 ±3.97),(35.07±5.72),(70.82±11.25), and there was a significant positive correlation between them(r=-0.555-0.483, P<0.05). Coping styles has a direct prediction on fear of progression(β =-0.207, β = 0.396, P<0.05), direct and indirect prediction on the quality of life(β = 0.184, β =-0.339, β = 0.074, β =-0.142, P<0.05). The intermediary effect accounted for 28.68% and29.52% of the total effect. Conclusion Fear of Progression is an important intermediate link of coping style affecting quality of life in ovarian cancer patients.