上皮性卵巢癌中USP39的表达及其临床意义

目的:探讨USP39在上皮性卵巢癌中的表达及临床意义。方法:收集2011~2014年郑州大学第一附属医院病理科的118例上皮性卵巢癌组织(54例卵巢浆液性囊腺癌、28例卵巢黏液性囊腺癌、19例卵巢内膜细胞癌、17例卵巢透明细胞癌)及40例卵巢良性肿瘤组织(20例卵巢浆液性囊性瘤、20例卵巢黏液性囊腺瘤)、24例正常卵巢组织的石蜡包埋组织。免疫组化法检测USP39表达,分析其表达与上皮性卵巢癌临床病理特征的相关性。结果:卵巢癌组织中USP39高表达率为72.03%(85/118),与卵巢良性肿瘤(19/40)及正常卵巢组织(5/24)相比,差异有统计学意义(P<0.05)。浆液性癌的USP39高表达率是85.19%(46/54),高于其他类型的癌,差异有统计学意义(P=0.032)。浆液性囊腺瘤(12/20)与黏液性囊腺瘤(7/20)相比,USP39高表达率无统计学差异(P=0.113)。上皮性卵巢癌中,USP39表达与患者年龄、肿瘤大小及肿瘤分化程度无关(P>0.05),而与病理类型、FIGO分期及淋巴结转移显著相关(P<0.05)。USP39高表达、FIGO分期及淋巴结转移是影响上皮性卵巢癌预后的独立危险因素(P<0.05)。结论:USP39表达升高与上皮性卵巢癌的发生发展有关,可能成为治疗上皮性卵巢癌的新靶点和评估预后的有力指标。

Expression and clinical significance of USP39 in epithelial ovarian cancer

Objective:To investigate the expression and clinical significance of USP39 in epithelial ovarian cancer.Methods:Paraffin-embedded tissue was collected in Pathology Department of First Affiliated Hospital of Zhengzhou University from 2011 to 2014,including 118 cases of epithelial ovarian cancer tissues(54 cases of ovarian serous cystadenocarcinoma,28 cases of ovary mucin cystadenocarcinoma,19 patients with ovarian endometrial carcinoma,17 cases of ovarian clear cell carcinoma) and 40 cases of ovarian benign tumor tissue(20 cases of ovarian serous cystic tumor,20 cases of ovarian mucous sex pouch adenomas),24 cases of normal ovarian tissue.USP39 expression was evaluated by means of immunohistochemical analysis and its relationship with epithelial ovarian cancer clinical pathological features were analyzed.Results:The expression rate of USP39 in ovarian cancer[72.03%(85/118)] was higher than that in ovarian benign tumors(19/40) and normal ovarian tissue(5/24),the difference was statistically significant(P<0.05).The positive expression rate of serous carcinoma[85.19%(46/54)] was significantly higher than that of other types of cancer(P=0.032).Compared serous tumors(12/20) with mucinous tumor(7/20),the positive expression USP39 had no statistical difference(P=0.113).The positive expression of USP39 in epithelial ovarian cancer had no relation with the patient’s age,tumor size and tumor differentiation degree(P>0.05),and had significantly association with pathologic types,FIGO staging and lymph node metastasis(P<0.05).The higher expression of USP39,FIGO staging,and lymph node metastasis were independent risk factors affecting the prognosis(P<0.05).Conclusion:The higher expression of USP39 is associated with the development of epithelial ovarian cancer,which may become the new target for treatment of epithelial ovarian cancer and powerful indicators for evaluation of prognosis.