乌梅枣仁汤对2型糖尿病合并睡眠障碍患者胰高血糖素、血糖变异性及睡眠质量的影响

目的探讨乌梅枣仁汤对2型糖尿病合并睡眠障碍患者胰高血糖素、血糖变异性及睡眠质量的影响。方法将2017年6月—2019年3月在山东省中医院治疗的122例2型糖尿病合并睡眠障碍患者随机分为2组,对照组61例采用常规西医治疗,研究组61例在常规西医治疗基础上加用乌梅枣仁汤治疗,2组均治疗4周。观察比较2组治疗前后中医症状积分、血糖指标空腹血糖(FPG)、餐后2 h血糖(2hPG)、胰高血糖素(GLC)]、血糖变异性相关指标日内平均血糖波动幅度(MAGE)、血糖波动最大幅度(LAGE)、血糖标准差(SDBG)]及匹兹堡睡眠质量指数量表评分(PSQI评分),比较2组不良反应发生情况。结果治疗后2组FPG、2hPG、GLC水平,临床症状积分,MAGE、LAGE、SDBG、PSQI评分均较治疗前明显降低(P均<0.05),且研究组治疗后上述各指标均明显低于对照组(P均<0.05)。研究组和对照组不良反应发生率分别为1.6%(1/61)、13.1%(8/61),2组间比较差异有统计学意义(P<0.05)。结论乌梅枣仁汤辅助治疗有助于降低2型糖尿病合并睡眠障碍患者血糖,控制血糖维持平稳,提高睡眠质量,且可减少不良反应。

Effect of Wumei Zaoren decoction on glucagon,blood sugar variability and sleep quality in patients with type 2 diabetes complicated with sleep disorder

Objective It is to investigate the effect of Wumei Zaoren decoction on glucagon,blood glucose variability and sleep quality in patients with type 2 diabetes mellitus and sleep disorders.Methods A total of 122 patients with type 2 diabetes mellitus and sleep disorders treated in Shandong Provincial Hospital of Traditional Chinese Medicine from June 2017 to March 2019 were randomly divided into 2 groups.The control group(n=61)was treated with conventional western medicine,and the study group(n=61)was treated with conventional western medicine plus Wumei Zaoren decoction,both groups were treated for 4 weeks.The TCM symptom scores,blood glucose indexesfasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glucagon(GLC)],blood glucose variability-related indicatorsthe mean amplitude of glycemic excursions(MAGE),largest amplitude of glycemic excursions(LAGE),blood glucose standard deviation(SDBG)]and the Pittsburgh Sleep Quality Index(PSQI scores before and after treatment were observed and compared in the two groups,the occurrence of adverse reactions in the two groups were compared.Results After treatment,the levels of FPG,2hPG,GLC,clinical symptom scores,MAGE,LAGE,SDBG,PSQI scores were significantly lower than those before treatment in the two groups(all P<0.05),and the above indicators after treatment in the study group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the study group and the control group were 1.6%(1/61)and 13.1%(8/61),respectively,and the differences between the two groups were statistically significant(P<0.05).Conclusion The adjuvant treatment with Wumei Zaoren decoction can help to reduce blood sugar,control blood sugar to maintain stability,improve sleep quality,and reduce adverse reactions in patients with type 2 diabetes and sleep disorders.