成都市新型冠状病毒肺炎患者的临床特征分析

目的 总结新型冠状病毒肺炎（COVID - 19）患者的临床特征。方法 回顾分析成都市公共卫生临床医疗中心收治的101例COVID - 19确诊病例的流行特点、临床特征、治疗及预后。采用Excel录入数据，SPSS 22.0对资料进行统计分析。结果 86.1%患者有明确流行病学接触史。主要临床症状表现为发热（75.2%），咳嗽（70.3%），咳痰（42.6%），乏力/肌肉酸痛（24%）。89.1%患者白细胞计数正常或降低，65.3%患者C反应蛋白升高，68.3%患者血清淀粉样蛋白升高，51.5%患者空腹静脉血糖升高，54.5%患者CD4+T淋巴细胞计数下降。胸部CT典型表现为磨玻璃样病灶，77.2%患者为双侧肺部均受累。101例患者中，轻型及普通型66例，重型及危重型35例。97.0%患者需要不同支持力度的氧疗，96.0%患者接受了抗病毒治疗、16.8%患者接受了抗细菌治疗，5.9%患者激素治疗。5.9%发生不同程度的急性呼吸窘迫综合征，16.8%发生继发感染，5.0%发生休克，2.0%发生急性肾损伤。截至2020年3月24日0:00治愈出院98例，死亡3例。结论 COVID - 19患者多数症状轻微，预后好；重型及危重型主要发生在高龄、合并高血压、糖尿病、慢性肾功能衰竭等基础疾病的患者，危重型患者可并发急性呼吸窘迫综合征，甚至多器官功能障碍危及生命，应早期识别及时治疗。

Analysis of the clinical characteristics of patients infected with novel coronavirus pneumonia in Chengdu

The study aimed to summarize the clinical characteristics of patients infected with novel coronavirus pneumonia. Methods The epidemic characteristics, clinical characteristics, treatment and prognosis of 101 cases of novel coronavirus pneumonia(COVID-19) admitted to Chengdu public health clinical medical center were analyzed retrospectively.EXCEL was used to input data and SPSS22.0 was used for statistical analysis. Results 86.1% of patients had a clear history of epidemiological exposure. The main clinical symptoms were fever(75.2%), cough(70.3%), sputum(42.6%), and fatigue/muscle soreness(24%). White blood cell count was normal or decreased in 89.1%; C-reactive protein was increased in 65.3%;serum amyloid was increased in 68.3%; fasting venous blood glucose was increased in 51.5% and CD4+T lymphocyte count was decreased in 54.5%. Chest CT showed a typical ground glass lesion, 77.2% of the patient was bilateral lung involvement.Of the 101 patients, 66 were mild and normal, and 35 were severe and critical. 97.0% of patients required oxygen therapy with varying levels of support; 96.0% received antiviral therapy; 16.8 % received antibacterial therapy, and 5.9% received corticosteroid therapy. 5.9% of the patients had different degrees of acute respiratory distress syndrome; 16.8% had secondary infection; 5.0% had shock and 2.0% had acute kidney injury. By 0:00 on March 24, 2020, 98 cases were cured and discharged, and 3 cases died. Conclusion Most patients with novel coronavirus pneumonia have mild symptoms and good prognosis. Severe patients mainly occur in the elderly, with hypertension, diabetes, chronic renal failure and other basic diseases. Critical patients may be complicated with acute respiratory distress syndrome, multiple organ failure and even death,which should be recognized early and treated timely.