贵州省侗族人群铅暴露水平与糖尿病前期、糖尿病的关联性初探

目的 探讨侗族人群铅暴露与糖尿病前期、糖尿病的关联性。方法 通过分层多阶段抽样调查贵州省侗族30～79岁之间的居民共3 225人，采用问卷调查、体格检查采集居民健康状况并收集生物样本，电感耦合等离子体质谱法来检测调查对象尿铅浓度，采用非条件logistic回归分析尿铅（四分位数）与糖尿病前期、糖尿病患病风险的关联性。结果 贵州省侗族人群尿铅浓度为2.87 μg(1.33～4.83 μg)，糖尿病患病率为9.02%(291/3 225人)，糖尿病前期患病率为48.00%(1 548/3 225人)，多因素校正后，尿铅浓度与糖尿病前期存在关联，尿铅浓度的第四分位与第一分位相比OR = 1.41(1.15,1.72)，未发现尿铅浓度与糖尿病之间有明显关联性。结论 贵州省侗族人群中尿铅浓度的升高与糖尿病前期风险具有关联性，未发现尿铅浓度与糖尿病患病风险存在关联性。

The correlation between lead exposure level and the prevalence of diabetes and prediabetes among Dong minority in Guizhou Province

To investigate the association of lead exposure with the prevalence of prediabetes and diabetes among Dong minority in Guizhou Province. Methods Through multi -stage stratified sampling survey, a total of 3225 males and females aged 30-79 years old in Dong people in southeastern province were surveyed with a questionnaire interview, physical examination, and laboratory tests. Urinary lead levels was assessed by inductively coupled plasma mass spectrometry (ICPMS). The prevalence of diabetes and prediabetes were compared across urinary lead quartiles. Results The median concentration of urinary lead was 2.87 μg/L (interquartile range: 1.33-4.83 μg/L). The prevalence of diabetes was 9.02%(291/3225) and the prevalence of diabetes was 48.00% (1548/3225). Elevated levels of urinary lead was associated with prediabetes (P<0.001) The odds ratios (95% confidence interval) for prediabetes in the third quartile was 1.409 (1.153, 1.722),respectively (referencing to 1.00). Total population found no significant correlation between urinary lead and diabetes.Conclusion Increased urinary lead concentration is associated with elevated prevalence of prediabetes and no find significant correlation between urinary lead and diabetes.