上海地区体检成人甲状腺自身抗体与甲状腺结节的相关性分析

目的 探讨上海地区体检成人血清甲状腺自身抗体与甲状腺结节的相关性及甲状腺结节患病的影响因素。方法 采用横断面研究方法整群选取2018年1 - 12月在华东疗养院进行健康体检的3 735人，根据甲状腺彩色超声结果分为甲状腺结节组和非甲状腺结节组，比较2组人群的一般资料、空腹血糖、三酰甘油、总胆固醇、甲状腺激素、抗甲状腺球蛋白抗体（TGAb）、抗甲状腺过氧化物酶抗体(TPOAb)等指标，分析TGAb、TPOAb与各指标的相关性及甲状腺结节的影响因素。结果 体检成人甲状腺结节患病率53.41%，女性高于男性(χ2 = 139.658， P＜0. 001)；甲状腺结节组的空腹血糖、舒张压、TGAb、TPOAb水平与非甲状腺结节组有统计学差异（P＜0.05）。血清TGAb、TPOAb与TSH呈正相关（P＜0.05）,与体重指数、血压、甘油三酯、空腹血糖成负相关（P＜0.05）。甲状腺结节多因素 logistic 回归分析显示，性别（OR = 2.310）、年龄（OR = 2.997）、血清TGAb、TPOAb滴度水平（OR = 1.796，1.788）与甲状腺结节发生相关。结论 上海地区成人甲状腺结节患病率高，年龄、性别、TGAB、TPOAB滴度水平可能是甲状腺结节发生的相关因素。

Correlation between the thyroid autoantibodies and thyroid nodule of adults in Shanghai area

The aim of this study was to investigate the correlation between serum thyroid autoantibodies and thyroidnodules in adults in Shanghai area and study the influencing factors of thyroid nodules. Methods By this cross -sectional studies, 3735 subjects who had come physical examination in East China Sanatorium from January to December, 2018 were recruited. According to the results of the thyroid color ultrasound, them were divided into the thyroid nodule and non-thyroidnodule group. The general information, triglyceride, total cholesterol, fasting blood glucose, TGAb, TPOAb and other indicators of the two groups were compared. The correlations between TGAb, TPOAb and each indexes, and the influencing factors of thyroid nodule were analyzed. Results The incidence of thyroid nodules in physical examination was 53.41%. It was higher in females than males (χ2 =139.658, P<0.001). Fasting glucose, diastolic blood pressure, TGAb and TPOAb levels in the thyroidnodule group were significantly higher than those in the non-thyroid nodule group (P<0.05). Serum TGAB and TPOAB levels were positively correlated with TSH levels (P<0.05), and negatively correlated with BMI, BMI, DBP, SBP, TG, and FBG (P<0.05).Multivariate logistic regression analysis of thyroid nodules showed that gender (OR=2.310), age (OR=2.997), serum TGAb and TPOAb levels (OR=1.796, 1.788) were correlated with thyroid nodules. Conclusion The incidence of thyroid nodules in adults in Shanghai was high, and the levels of TGAB and TPOAB, gender, age were influencing factors for thyroid nodules.