中国老年2型糖尿病患者抑郁患病率的Meta分析

目的 系统评价中国老年2型糖尿病(T2DM)患者发生抑郁的患病率现状。方法 计算机检索WanFang Data、VIP、CNKI、CBM、PubMed和Embase等数据库，搜集有关中国老年T2DM患者发生抑郁情况的横断面研究。通过筛选、资料提取及质量评价后，采用Stata 14.0软件进行Meta分析。结果 纳入19项研究结果显示，老年T2DM患者发生抑郁的合并患病率为40%(95%CI:38%～41%)。亚组分析显示，不同性别、婚姻状况、抑郁程度、文化程度和调查时间的患病率差异均有统计学意义，不同区域、地区和人群来源的患病率差异均无统计学意义。其中老年T2DM患者的抑郁程度多以轻中度为主(P＜0.001)，女性45%(95%CI:42%～48%)高于男性34%(95%CI:30%～37%)(P＜0.001)，在婚状态的抑郁患病率37%(95%CI:33%～40%)低于离异或丧偶状态46%(95%CI:41%～52%) (P = 0.002)，文化程度在高中以上的抑郁患病率47%(95%CI:42%～53%)低于高中及以下56%(95%CI:52%～59%)(P = 0.011)，老年T2DM患者抑郁的患病率在1999 - 2019年期间一直持续处于较高水平(P = 0.001)。结论 我国老年T2DM患者抑郁的患病率较高，应在其临床治疗和护理干预中进一步增强心理干预，防止抑郁并发症的发生。

Prevalence of depression in Chinese elderly patients with type 2 diabetes: a meta-analysis

The study aimed to systematically evaluate the prevalence of depression in elderly T2 DM patients in China. Methods This paper retrieved WanFang Data, VIP, CNKI, CBM, PubMed and Embase database to collect cross-sectional studies about the prevalence of depression in elderly T2 DM patients. Meta-analysis was performed using Stata 14.0 software after screening, data extraction and quality assessment. Results A total of 19 studies were included. The analysis results showed that prevalence rate of depression in elderly patients with T2 DM was 40%(95%CI:38% to 41%). The subgroup analysis showed that the differences in the prevalence of depression among gender, marital status, degree of depression,education level and survey time were statistically significant, while there was no statistically significant difference in prevalence among districts, regions and population sources. The depression degree of elderly patients with T2 DM was mainly mild and moderate(P<0.001), female prevalence of 45%(95%CI: 42% to 48%) was higher than male 34%(95%CI: 30% to37%)(P<0.001). The prevalence of depression in married elderly T2 DM patients was 37%(95%CI:33% to 40%), lower than that of 46%(95%CI: 41% to 52%)(P=0.002) in elderly T2 DM patients who were divorced or widowed. The prevalence of depression in elderly T2 DM patients with educations above high school was 47%(95%CI: 42% to 53%), lower than that of 56%(95%CI: 52% to 59%)(P=0.011) in elderly T2 DM patients with high school education or below. The prevalence of depression in elderly T2 DM patients remained at a consistently high level from 1999 to 2019(P =0.001). Conclusion The prevalence of depression in elderly T2 DM patients in China is relatively high, so enhanced psychological intervention should be further strengthened in clinical treatment and nursing intervention to prevent the occurrence of depressive complications.