血府逐瘀汤联合心脉隆注射液对急性冠脉综合征患者PCI术后NT-proBNP、CRP及心功能的影响

目的观察血府逐瘀汤联合心脉隆注射液对急性冠脉综合征患者PCI术后N-末端脑钠肽前体(NT-proBNP)、C反应蛋白(CRP)及心功能的影响。方法将2017年7月-2018年12月河北省沧州中西医结合医院收治的200例急性冠脉综合征PCI术后患者按照随机单盲法分为2组各100例,对照组术后常规给予抗血小板、抗凝、降脂、降压、扩张冠状动脉等西医常规治疗,观察组在此基础上加用血府逐瘀汤颗粒剂(1剂/d)口服、心脉隆注射液100 mg静脉滴注(1次/d)。2组患者疗程均为10 d。比较2组患者治疗有效率、心功能指标左室射血分数(LVEF)、每搏量(SV)、心脏指数(CI)]、血浆NT-proBNP、CRP及不良反应情况。结果治疗10 d后,观察组治疗总有效率为92%(92/100),对照组为74%(74/100),观察组明显高于对照组(P<0.05)。治疗10 d后观察组EF、SV、CI均较治疗前明显升高(P均<0.05),NT-proBNP、CRP水平均较治疗前明显降低(P均<0.05);对照组LVEF、SV均较治疗前明显升高(P均<0.05),NT-proBNP、CRP水平均较治疗前明显降低(P均<0.05),但CI较治疗前无明显改善(P>0.05);组间比较,治疗后观察组各项指标较对照组改善更明显(P均<0.05)。2组患者治疗期间均未见明显不良反应发生。结论血府逐瘀汤联合心脉隆注射液可改善急性冠脉综合征患者PCI术后血液循环,减轻心脏负担及改善心功能,且安全性高。

Effects of Xuefu Zhuyu Decoction combined with Xinmailong injection on NT-proBNP,CRP and cardiac function in patients with acute coronary syndrome after PCI

Objective It is to observe the effects of Xuefu Zhuyu Decoction combined with Xinmailong injection on N-terminal brain natriuretic peptide precursor(NT-proBNP), C-reactive protein(CRP) and cardiac function in patients with acute coronary syndrome after PCI. Methods 200 patients with acute coronary syndrome after PCI who were treated in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from July 2017 to December 2018 were selected and randomly divided into 2 groups according to the randomized single-blind method, 100 patients in each group. The control group was given normal therapy such as antiplatelet, anticoagulant, lipid-lowering, antihypertensive, expanding coronary arteries after the surgery, the observation group was added Xuefu Zhuyu Decoction granules(1 dose/d), Xinmailong injection 100 mg by intravenous drip, 1 time/d. The course of treatment in both groups was 10 days. The treatment efficiency, cardiac function index(LVEF,SV CI), plasma NT-proBNP, CRP, and adverse reactions were compared between the two groups. Results After 10 days of treatment, the total effective rate in the observation group was 92%(92/100) and that in the control group was 74%(74/100), the observation group was significantly higher than the control group(P<0.05). After 10 days of treatment, the EF, SV, and CI in the observation group were significantly higher than those before treatment(P<0.05), and the levels of NT-proBNP and CRP were significantly lower than before treatment(P<0.05). The LVEF and SV in the control group were all higher while the levels of NT-proBNP and CRP were significantly lower after treatment than those before treatment(P<0.05), but CI was not significantly improved compared with that before treatment(P>0.05). Compared with each other, the improvement of these indexes was more obvious in the observation group than that of the control group(P<0.05). No significant adverse reactions occurred during the treatment in the two groups. Conclusion Xuefu Zhuyu Decoction combined with Xinmailong injection can improve blood circulation, reduce cardiac burden and improve cardiac function with high safety in patients with acute coronary syndrome after PCI.