盐酸替罗非班联合心血管介入治疗急性心肌梗死病人的临床效果与安全性研究

目的 探索盐酸替罗非班联合心血管介入治疗急性心肌梗死病人的临床效果与安全性.方法 将行心血管介入治疗的109例急性心肌梗死病人分为研究组(n=56)和对照组(n=53),比较盐酸替罗非班的作用效果.结果 行冠状动脉介入治疗(PCI)术后,研究组心肌灌注2级4例(7.14%),3级52例(92.86%);对照组心肌灌注1级5例(9.43%),2级11例(20.75%),3级37例(69.81%),研究组心肌灌注情况明显优于对照组(P<0.05).PCI术后,心肌梗死溶栓(TIMI)血流分级在2、3级上两组之间差异有统计学意义(P<0.05).研究组和对照组术后12 h的肌酸激酶同工酶(CK-MB)水平差异有统计学意义(P=0.001).研究组在术后1个月内发生不良事件发生率显著低于对照组(P<0.05).结论 盐酸替罗非班联合心血管介入治疗能够有效提高病人急性心肌梗死后的灌注状况,降低心血管事件的发生概率,是急诊心脏介入有效而安全的手段.

Clinical effect and safety research of tirofiban hydrochloride using in cardiovascular interventional treatment of patients with acute myocardial infarction the treatment of severe brain injury in the postoperative by near infrared spectroscopy

Objective To explore clinical effect and safety of tirofiban hydrochloride using in cardiovascular interventional treatment of patients with acute myocardial infarction.Methods 109 patients with acute myocardial infarction who received cardiovascular interventional treatment were divided into research group (n=56) and control group (n=53) to compare the effect of Tirofiban Hydrochloride.Results After percutaneous coronary intervention((PCI),the TIMI myocardial perfusion grading(TMPG) level 2 of research group were 4 cases (7.14%),level 3 were 52 cases (92.86%);the TMPG level 1 of control group were 5 cases (9.43%),level 2 were 11 cases (20.75%),level 3 were 37 cases (69.81%),the TMPG of research group was superior to the control group(P<0.05).After percutaneous coronary intervention(PCI), on level 2,3,thrombolysis in myocardial infarction(TIMI)flow grade were significant difference between the two groups (P<0.05).Differences of creatine kinase-MB(CK-MB) level after 12 h between research group and the control group was not statistically significant (P=0.001).The incidence of cardiovascular events in the research group within a month was significantly lower than that in the control group (P<0.05).Conclusion Tirofiban Hydrochloride combined with cardiovascular intervention can effectively improve the perfusion status of patients after acute myocardial infarction,reduce the incidence of cardiovascular events,is an effective and safe means of emergency cardiac intervention.