经导管主动脉瓣置换术的研究进展

主动脉瓣狭窄(AS)是老年人最常见的瓣膜退行性改变,发病率正逐年上升.经导管主动脉瓣置换术(TAVR)的临床应用为AS患者提供了一种全新的治疗方法 ,目前TAVR已经成为不能进行外科手术或具有高外科手术风险的重度AS患者的有效替代治疗方案.欧美国家开展的TAVR注册研究进一步肯定了TAVR的效果.近期一些重要的随机对照临床试验及注册研究结果 已经报道,现将近期重要的试验结果 作一综述.

Research status and progress of transcatheter aortic valve implamtation

Aortic stenosis(AS) is the most common degenerative valvular disease in the elderly,and its incidence is increasing annually.Transcatheter aortic valve replacement (TAVR) is a feasibly alternative treatment for patients with severe aortic stenosis and prohibitive/high operative risk.TAVR registry studies carried out in Europe and the united states further affirm the effectiveness of TAVR.Recently,some randomized controlled clinical trials and registry studies have been reported.This paper aims to review the results of important trials and registries.