某三甲医院2012-2015年抗菌药物使用强度与鲍曼不动杆菌耐药性的相关性分析

目的 通过对某三甲医院2012-2015年抗菌药物的使用强度与鲍曼不动杆菌对临床常用的各类抗菌药物的耐药性分析,探讨抗菌药物使用强度与鲍曼不动杆菌耐药性之间的关系,为临床合理用药提供参考依据.方法 回顾性调查某三甲医院2012-2015年住院病人常用抗菌药物的用药频度和用药强度,并统计鲍曼不动杆菌对常用抗菌药物的耐药率,利用SPSS 21.0统计软件进行相关性数据分析.结果 鲍曼不动杆菌对头孢哌酮/舒巴坦的耐药率与β-内酰胺类/β-内酰胺酶抑制剂的使用强度呈正相关(r=1,P<0.01),多重耐药鲍曼不动杆菌检出率与头孢哌酮/舒巴坦的使用强度呈显著正相关(r=1,P<0.01).结论 合理控制β-内酰胺类/β-内酰胺酶抑制剂的使用,在一定程度上可减缓鲍曼不动杆菌耐药的产生.

Correlation between antibacterial use density and resistance of acinetobacter baumanniiin a 3A hospital

Objective To investigate the correlation between antimicrobial usedensity and resistance of acinetobacter baumannii in a grade 3 hospital from 2012 to 2015 and to provide information for rational use of antibiotic drugs.Methods Data of defined daily doses (DDDs) and antibacterial use densityof common antibiotics were analyzed ininpatients from 2012 to 2015.Drug resistance rate of acinetobacter baumannii to different antibiotics were investigated.Spearman correlation analysis was conducted by SPSS 21.0.Results The resistance rates of acinetobacter baumannii on cefoperazone and sulbactam were significantly positively related to the consumption of β-lactam/β-lactamases inhibitor (r=1,P<0.01).The detection rate of multidrug resistant acinetobacter baumannii was positively related to the use of cefoperazone and sulbactam (r=1,P<0.01).Conclusions The rational controlofbeta-lactams /beta-lactamase inhibitors use can reduce to a certain extent the resistance rate of acinetobacter baumannii.