地塞米松复合右美托咪定对腰麻后头痛的预防作用

目的 探讨地塞米松复合右美托咪定对腰麻后头痛的预防作用.方法 选取拟行腰麻下手术的患者50例,采用随机数字表法分为两组:地塞米松+氟比洛芬酯组(DF组)和地塞米松+右美托咪定组(DD组),每组25例.两组患者分别于手术结束时给予静脉注射地塞米松(10 mg)+氟比洛芬酯(1 mg·kg-1)和地塞米松(10 mg)+右美托咪定(1μg·kg-1).记录两组患者术后6、12、24、48、72 h的头痛发生率视觉模拟评分(VAS) ＞3分记为头痛阳性];记录两组患者腰背胀痛、恶心呕吐等不良反应.结果 与DF组相比,DD组术后24 ～ 48 h头痛发生率明显降低(P＜0.05),且术后恶心、呕吐发生率明显降低(P＜0.05).结论 地塞米松复合右美托咪定可明显降低腰麻后头痛的发生率,但对腰麻后头痛程度无明显影响.

Comparison of dexamethasone combined with dexmedetomidine and flurbiprofen axetil for the prevention of post-dural puncture headache

Objective To probe the effection of dexamethasone combined with dexmedetomidine for the prevention of post-dural puncture headache.Methods All of 50 patients were randomly allocated into two groups (n =25):dexamethasone + flurbiprofen axetil (DF group) and dexamethasone + dexmedetomidine (DD group).The tevel of postoperative headache at the time of 6,12,24,48,and 72 h postoperatively were measured based on Visual Analog Scale (＞ 3 was elected as positive result)criterion in the two groups and then compared with each other.In addition,backache,nausea and vomiting were also recorded.Results Compared with group DF,the level of postoperative headache were declined significantly at the time of 24 h to 48 h.Meanwhile,postoperative nausea and vomiting were fewer.Conclusions Though the taking of dexamethasone combined with dexmedetomidine was associated with a decrease in post-dural puncture headache incidence.However,no essentially and statistically significant effect of post-dural puncture headache intensity is produced.