N端脑利钠肽前体在肺部感染患者机械通气中的指导作用

目的 研究N端脑利钠肽前体(NT-PROBNP)对患者采用机械通气及脱机治疗时机的指导意义.方法 选取使用呼吸机的肺部感染患者48例,测定患者使用呼吸机前、使用呼吸机时、成功撤机后的动脉血NT-PROBNP浓度及相对应的患者心衰分级,观察并比较患者血液中NT-PROBNP浓度的变化及心衰程度的改变.结果 患者使用呼吸机前的NT-PROBNP浓度及心衰分级小于使用呼吸机时的NT-PROBNP浓度及心衰分级 (P<0.001);成功撤机后的NT-PROBNP浓度及心衰分级小于使用呼吸机时的NT-PROBNP浓度及心衰分级 (P<0.001).结论 NT-PROBNP对肺部感染患者是否采用机械通气及脱机治疗具有指导意义.

The guiding role of NT-PROBNP in the mechanical ventilation of patients with lung infection

Objective To explore the guiding role of NT-PROBNP in the mechanical ventilation of patients with lung infection.Methods We chose 48 patients with lung infection who were treated with ventilator,measured the arterial blood concentration of NT-PROBNP and the classification of patients′ heart failure before,during and after the use of ventilator,observed and compared the change of the arterial blood concentration of NT-PROBNP and the degree of heart failure.Results Blood concentration of NT-PROBNP and the heart failure classification were lower before the use of ventilator than during the use of ventilator (P<0.001).Blood concentration of NT-PROBNP and the heart failure classification were lower after the use of ventilator than during the use of ventilator(P<0.001).Conclusions The NT-PROBNP can provide a reference to mechanical ventilation of patients with lung infection.