自噬基因Beclin1与膀胱癌关系的研究进展

近年来,自噬与癌症的关系是癌症研究领域的热点.自噬作为重要的生物学过程,几乎参与生理、病理的所有过程.自噬基因Beclin1作为非常重要的自噬调节物,是自噬必不可少的,也被认为是一种肿瘤抑制因子.研究表明自噬基因Beclin1作为一把"双刃剑",在肿瘤的发生、发展、转移、预后及对抗耐药治疗中起着至关重要的作用.目前自噬基因Beclin1在膀胱癌发生、发展各个阶段的具体作用机制还不清楚,研究其与膀胱癌的关联,对于膀胱癌的治疗靶点选择、预后及耐药机制的明确均有重要的科学意义.

Research on autophagy-related gene Beclin1 and bladder cancer

In recent years,much attention has been focused on autophagy and cancer.Autophagy is involved with almost all physiological and pathological processes.Autophagy-related gene Beclin1 which is essential for autophagy,and it is an very important autophagy modulator and also known as a tumor suppressor.Studies have shown that autophagy gene Beclin1 as a "double-edged sword" plays an important role in tumor occurrence,development,metastasis,prognosis and drug resistance.So far,the mechanism of Beclin1 related bladder cancer occurrence and development is much unknown.Therefore,the study of the relationship between Beclin1 and bladder cancer will be useful for seeking for new cancer therapeutic targets,assessing prognosis and reducing drug resistance.