| 苏贝止咳颗粒中挥发油的质量标准初步研究 |
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| 引用本文： | 袁青青,崔颖,王浩,田军,刘永,孙备,吕凌.苏贝止咳颗粒中挥发油的质量标准初步研究[J].安徽医药,2017,21(11):1994-1997. |
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| 作者姓名： | 袁青青 崔颖 王浩 田军 刘永 孙备 吕凌 |
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| 作者单位： | 安徽中医药大学,安徽 合肥,230012;安徽省食品药品检验研究院,安徽省中药研究与开发重点实验室,安徽 合肥 230051 |
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| 摘 要： | 目的 建立苏贝止咳颗粒中挥发油成分的质量标准.方法 采用气相色谱-质谱联用(GC-MS)对挥发油提取物的成分进行鉴定,共鉴定出10个色谱峰;采用气相色谱法(GC)测定制剂中挥发油的含量,其中 α-蒎烯、β-蒎烯、柠檬烯采用外标法进行测定.结果 α-蒎烯、β-蒎烯、柠檬烯线性范围分别为0.5908～75.625 mg·L-1(r=1),0.7781～24.90 mg·L-1(r=1),1.7194～220.08 mg·L-1(r=1),平均加样回收率分别为102.68％(RSD=4.82％)、108.09％(RSD=6.45％)和95.59％(RSD=5.43％)(n=9).结论 所建立的方法准确、可靠、专属性强,增加了能反映制剂临床疗效的质量控制指标,为质量标准的完善提供依据.
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| 关 键 词： | 苏贝止咳颗粒 挥发油 气相色谱法 气相色谱-质谱联用 |
| 收稿时间： | 2017/3/21 0:00:00 |
| 修稿时间： | 2017/4/13 0:00:00 |
Quality standard study of the volatile oil of Subei zhike granules |
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| YUAN Qingqing,CUI Ying,WANG Hao,TIAN Jun,LIU Yong,SUN Bei and LYU Ling.Quality standard study of the volatile oil of Subei zhike granules[J].Anhui Medical and Pharmaceutical Journal,2017,21(11):1994-1997. |
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| Authors: | YUAN Qingqing CUI Ying WANG Hao TIAN Jun LIU Yong SUN Bei and LYU Ling |
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| Institution: | Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230012,China,Anhui Institute of Food and Drug Control,Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei,Anhui 230051,China,Anhui Institute of Food and Drug Control,Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei,Anhui 230051,China,Anhui Institute of Food and Drug Control,Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei,Anhui 230051,China,Anhui Institute of Food and Drug Control,Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei,Anhui 230051,China,Anhui Institute of Food and Drug Control,Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei,Anhui 230051,China and Anhui Institute of Food and Drug Control,Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei,Anhui 230051,China |
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| Abstract: | Objective To establish quality standard of Subei zhike granules volatile oil constituents. Methods The constituents of the volatile oil extracts were identified by GC-MS,there were 10 chromatographic peaks identified. The content of volatile oil was determined by GC,α-pinene,β-pinene and limonene were determined by the external standard method. Results The linearity ranges of α-pinene,β-pinene,Limonene were 0. 5908-75. 625 mg·L - 1 (r = 1),0. 7781-24. 90 mg·L - 1 (r = 1),1. 7194-220. 08 mg·L - 1 (r = 1),re-spectively. The average recovery rate was 102. 68％ (RSD = 4. 82％ ),108. 09％ (RSD = 6. 45％ ) and 95. 59％ (RSD = 5. 43％ )(n =9),respectively. Conclusions The establishment of accurate,reliable,specific method can reflect the quality control indicators of clini-cal efficacy and provide a basis for improvement of quality standards. |
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| Keywords: | Subei zhike granules Volatile oil GC GC-MS |
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