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Alloreactive natural killer cells in hematopoietic stem cell transplantation |
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| Authors: | Hollie J. PegramDavid S. Ritchie Mark J. Smyth Andres Wiernik H. Miles Prince Phillip K. Darcy Michael H. Kershaw |
| Affiliation: | a Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Australia b Department of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia c Department of Pathology, University of Melbourne, Melbourne, Australia d Division of Adult Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA e Department of Medicine, Hennepin County Medical Center, Minneapolis, MN, USA f Department of Immunology, Monash University, Victoria, Australia |
| Abstract: | Allogeneic hematopoietic stem cell transplantation (HSCT) for leukemia can play a major role in reducing the risk of relapse by inducing a graft versus leukemia (GVL) effect. Here, we review the effectiveness of mismatching inhibitory killer-cell-immunoglobulin-like receptors (KIR) on donor natural killer (NK) cells as a mechanism for GVL. We review the range of KIR and the importance of T cell and NK cell content of the graft, together with considerations of the graft source. Further understanding of conditioning and mechanisms to reduce graft versus host disease (GVHD) will improve our ability to manipulate NK cells in HSCT. |
| Keywords: | Graft versus leukemia Immunotherapy Acute myeloid leukemia Graft versus host disease Allogeneic stem cell transplantation KIR |
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