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Role of Rho-ROCK signaling in MOLT4 cells metastasis induced by CCL25 |
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| Authors: | Li ZhangBeibei Yu Meng HuZhan Wang Dongying LiuXiaoling Tong Jun LengBeibei Zhou Yi HuRanran Wu Qianshan DingQiuping Zhang |
| Affiliation: | a Department of Immunology, College of Basic Medical Science, Wuhan University, 185 Donghu Road, Wuhan, 430071 Hubei, China b Department of Microbiology, College of Basic Medical Science, Wuhan University, Wuhan, China |
| Abstract: | Our previous research has revealed that binding of the chemokine CCL25 to the CCR9 provides chemotactic cues guiding leukemic cells to specific tissues and organs. The RhoA-ROCK pathway might be involved in cancer migration. The purpose of this study was to explore the role of the RhoA-ROCK-MLC axis in leukemic cell migration following exposure to CCL25. The results showed that CCL25 could increase the amount of the GTPase RhoA and activate MLC in MOLT4 cells in a time-dependent manner. C3 exoenzyme and Y-27632 could block MOLT4 cell migration and chemotaxis. Thus, the RhoA-ROCK-MLC axis might play an important role in MOLT4 cell metastasis induced by CCL25. |
| Keywords: | CCR9 RhoA-ROCK-MLC CCL25 MOLT4 Metastasis Polarization |
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