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Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma: a single institutional experience and literature review |
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| Authors: | Liu Jane Jijun Zhang Ling Ayala Ernesto Field Teresa Ochoa-Bayona Jose L Perez Lia Bello Celeste M Chervenick Paul A Bruno Salvador Cultrera Jennifer L Baz Rachid C Kharfan-Dabaja Mohamed A Raychaudhuri Jyotishankar Sotomayor Eduardo M Sokol Lubomir |
| Institution: | a Department of Hematology and Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive MCC-GME, Tampa, FL, USA b Department of Hematopathology and Clinical Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA c Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA d Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA |
| Abstract: | Plasmablastic lymphoma (PBL) is a rare aggressive B-cell lymphoproliferative disorder. HIV-negative PBL has not been extensively reported. Nine HIV-negative PBL patients evaluated at Moffitt Cancer Center were studied. Eight patients had extranodal diseases. All patients were treated with CHOP or hyper-CVAD. Responses were observed in 8 cases (7 complete, 1 partial responses). Four patients underwent consolidation with autologous hematopoietic stem cell transplant (HSCT) in first complete remission (CR1). At median follow-up of 23.9 months, 7 patients were alive and 5 were disease-free. Aggressive induction chemotherapy and consolidation with autologous HSCT in CR1 might be considered for patients with HIV-negative PBL. |
| Keywords: | Plasmablastic lymphoma HIV-negative patients Stem cell transplant |
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