Race and intensity of post-remission therapy in acute myeloid leukemia期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Race and intensity of post-remission therapy in acute myeloid leukemia

Authors:	Anna K BradyAlex Z Fu Marc EarlMatt Kalaycio Anjali AdvaniYogen Saunthararajah Ronald SobecksEdward Copelan Mikkael A Sekeres

Institution:	Leukemia Program, Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA

Abstract:	Background In many cancers, including AML, blacks have poorer overall survival. We investigated whether differences in post-remission therapy (PRT) were a contributing factor. Methods We compared PRT cycle number and intensity and time to PRT in blacks and whites, among 460 patients with newly diagnosed AML. Results Blacks and whites had PRT of equal cycle intensity and number, but black patients experienced a significant delay in starting PRT (2.73 months in blacks vs. 1 month in whites, p = 0.047). Overall survival was equivalent in blacks and whites. Conclusion PRT is delayed in blacks but does not explain differences in survival.

Keywords:	Acute myeloid leukemia Health disparities Treatment outcomes Survival analysis
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