| 阻塞性睡眠呼吸暂停综合征患儿T细胞亚群水平及相关指标的分析 |
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| 引用本文： | 卢红霞,范献良,任惠兰. 阻塞性睡眠呼吸暂停综合征患儿T细胞亚群水平及相关指标的分析[J]. 临床耳鼻咽喉头颈外科杂志, 2004, 18(9): 519-520 |
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| 作者姓名： | 卢红霞 范献良 任惠兰 |
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| 作者单位： | 山东大学卫生部耳鼻喉重点实验室,济南,250012;山东大学齐鲁医院耳鼻咽喉科 |
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| 基金项目： | 山东省科技厅资助项目 (BBICAA3) |
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| 摘 要： | 目的 :检测阻塞性睡眠呼吸暂停综合征 (OSAS)患儿外周血T细胞亚群的变化 ,探讨OSAS对其细胞免疫功能的影响。方法 :应用APAAP桥联酶标法测定OSAS组和正常对照组外周血淋巴细胞表型 ,并将结果与睡眠检测指标进行相关性分析。结果 :OSAS组与正常对照组比较 ,CD4 、CD8 、CD4 /CD8 差异均有统计学意义 (均P <0 .0 1) ;CD4 、CD8 、CD4 /CD8 与呼吸暂停指数无相关性 ;与最低血氧饱和度 (LSaO2 )和病程有相关性 ,LSaO2 越低、病程越长 ,对T细胞亚群的影响越大 (P <0 .0 5 )。结论 :OSAS患儿细胞免疫功能低下。
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| 关 键 词： | 睡眠呼吸暂停综合征 阻塞性 儿童 细胞免疫 |
| 文章编号： | 1001-1781(2004)09-0519-02 |
| 修稿时间： | 2003-12-15 |
T cell immunity analysis in children with obstructive sleep apnea syndrome |
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| LU Hongxia FAN Xianliang REN Huilan. T cell immunity analysis in children with obstructive sleep apnea syndrome[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2004, 18(9): 519-520 |
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| Authors: | LU Hongxia FAN Xianliang REN Huilan |
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| Affiliation: | The Institute of Otolaryngology of Shandong University, Jinan, 250012, China. |
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| Abstract: | OBJECTIVE: To probe into the possible impact on T cell immunity in children with obstructive sleep apnea syndrome (OSAS). METHOD: Lymphocytes in peripheral blood vessel of children with OSAS vs normal controls were checked by APAAP method and analyzed statistically. RESULT: The comparison with the controls showed that CD3+ had no significant difference (P>0.05), CD4+, CD4+/CD8+ were significantly lower, CD8+ was significantly higher in children with OSAS (P<0.01), and the analysis of the LSaO2 and period of history showed that the lower the LSaO2, and the longer the period of history, the more effect to CD4+, CD8+, CD3+/CD8+ (P<0.05). CONCLUSION: T cell immunity are impaired in children with OSAS. |
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| Keywords: | Obstructive sleep apnea syndrome Children T cell immunity |
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