新疆不同人群血清中TTV病毒流行病学调查

目的 了解新疆地区不同民族，不同人群中TTV－DNA病毒的感染情况及流行病学特征。为进一步研究新疆人群中TTV－DNA病毒的分布，分子生物学性状及临床诊断奠定基础。方法 应用微板－核酸杂交PCR－ELISA技术对采集到的血样进行了TTV－DNA检测，同时进行肝功能及其他各型肝炎的检测。结果 本次共检测了不同人群的血要201人份，TTV－DNA的阳性率为12．93％（26／201）。民族与性别分布，汉族为13．04％（15／155），维吾尔族为12．79％（1／186），女性17．31％（9／52），明显高于男性11．41％（17／149）。在不同人群中，已排除甲－庚型肝炎的单纯转氨酶增高者TTV－DNA阳性率为21．05％（8／38），HIV阳笥人群中TTV－DNA阳性率为18．36％（9／49）；一般肝炎病人阳性率为13．64％（9／66），透析人群及正常对照人群中未检出阳笥。结论 TTV－DNA的阳性率为12．93％（26／201），不同民族和性别的阳性率不同。

Epidemiological investigation on TTV infection in sera of different population from Xinjiang

Objective To know the infective state and epidemiological characteristic of TTV_DNA virus in different population and nationalities from Xinjiang, and provide a basis for further research on the distribution, molecular biology character and clinical diagnosis of TTV_DNA infection in people from Xinjiang. Methods The collected serum samples were determined in the meantime,liver function and hepatitis of the other types were also detected.Results There were totally 201 samples of sera of different population detected. The positive rate of TTV_DNA infection was 12.93%(26/201).The distributions of TTV_DNA infection in nationalities and sex were 13.04% in Han people (15/115) and 12.79% in Uygur population (11/86),as well as 17.31% in female(9/52)which washigher than 11.41% in male(17/149). After evacuation of simple transaminase increase of patients with hepatitis A_G in different population, the positive rate of TTV_DNA infection was 21.05%(8/38),while it was 18.36% (9/49) in people with positive HIV,and 13.64%(9/66) in ordinary patients with hepatitis. No positiveness was detected in dialysis and normal people.Conclusion There was TTV infection in Xinjiang,with infective rate of 12.93%(26/201). No obvious difference was found in various nationalities and sex.The infective rate was the highest to be 21.05% (8/38) in people without simple transaminase increase of hepatitis A_G.