| 钌红对内毒素多种生物活性的拮抗作用 |
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| 引用本文： | 颜亮,唐海兰.钌红对内毒素多种生物活性的拮抗作用[J].中国病理生理杂志,1993,9(3):355-357. |
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| 作者姓名： | 颜亮 唐海兰 |
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| 作者单位： | 暨南大学医学院病理生理学教研室
(颜亮，杨皓荘)，暨南大学医学院病妇产科教研室
(唐海兰)，暨南大学医学院病理生理学教研室(李楚杰) |
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| 摘 要： | 钌红对内毒素的鲎试剂凝集反应、局部Shwartzman反应、降低外周血白细胞计数和血清锌的含量等效应均有拮抗作用。电镜下可见经钌红处理过的内毒素呈无规律絮状凝聚,正常网状结构被破坏。用三硝基苯磺酸法证实钌红与内毒素结合,使其氨基含量大增。以上结果提示:钌红的多阳离子氨基可能是对内毒素多种生物活性起拮抗作用的有效结构。
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| 关 键 词： | 钌红 内毒素 鲎试验 |
Antagonistic effects of ruthenium red on the biological activities of endotoxin |
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| Yan Liang,Tang Hai-Lan,et al.Antagonistic effects of ruthenium red on the biological activities of endotoxin[J].Chinese Journal of Pathophysiology,1993,9(3):355-357. |
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| Authors: | Yan Liang Tang Hai-Lan |
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| Affiliation: | Yan Liang,Tang Hai-Lan,et al Department of Pathophysiology,Medical College of Jinan University,Guangzhou |
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| Abstract: | The antagonistic effects of ruthenium red (RuR) on the biological activi-
ties of endotoxin (ET) which included the limulus amebocytes lysate test, the local Shw-
artzman reaction, decreasing the white blood cell counts, and increase of zinc in periphe-
ral blood were observed. The destroyed meshes of endotoxin have been seen under electron
microscope. The amino-groups of endotoxin increased markedly, which it was treated with
RuR. These results indicated that the polycationic residues of RuR may be the effective
units of antiendotoxin activity. |
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| Keywords: | Ruthenium red Endotoxins Limulus test |
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