外源性磷酸肌酸对冠状动脉搭桥病人围术期免疫系统的影响

目的 观察用外源性磷酸肌酶（ＣＰ）对冠状动脉搭桥（ＣＡＢＧ）病人围术期补体及免疫球蛋白的变化,评价其对免疫系统的影响。方法 ２８例ＣＡＢＧ病人随机分为ＣＰ组１７例,对照组１１例,ＣＰ组于术前、后备用ＣＰ３～７ｄ,每天２ｇ静脉滴注,术中将ＣＰ加入心脏停搏液中,对照组椁前、中、后均不用ＣＰ。观察两组病人术前１周、麻醉诱导后、术中阻断升主动脉后５、３５、６５ｍｉｎ（１４例病人）、术毕、术后２４ｈ、术后１

Perioperative influence of exogenous creatine phosphate on immune system in coronary artery bypass grafting

Objective To evaluate the Perioperative influence of exogenous creatine phosphate (CP) on immune system in coronary artery bypass grafting by observing the changes of completment and immunoglobulin. Method 28 patients were divided into control group (n=11) and CP group (n=17). In the CP group, CP was given perioperatively (2g/day intravenously for 3(7days) and during operation (10 mmol/L added into cardioplegia). In the control group, no CP was given. The changes of completment (C3, C4) and immunoglobulin (IgA, IgG, IgE, IgM) were documented at eight different time intervals. Results The trends of changes were similar in both groups. In CP group, all values were lower, especially the values of C3, C4, IgG, IgM. The perioperative and early postoperative values showed no significant difference with exception of those at 1 week after operation (P<0.05). Conclusion the data indicates that exogenous creatine phosphate used in the patients of CABG perioperatively may have protective effect on complement and immunoglobulin, the definitive mechanism is not clear, and needs further study.