乳腺癌组织中p53、nm23-H1基因表达及其与绝经状态、淋巴结转移的相关性

目的]研究乳腺癌患者中p53和nm23-H1基因表达,及其与绝经状态及腋窝淋巴结转移的关系.方法]采用免疫组织化学SP方法检测60例乳腺癌组织中p53和nm23-H1的表达.结果]60例乳腺癌患者中,p53和nm23-H1的阳性表达率分别为73.3%(44/60)和66.7%(40/60);在绝经前患者中p53和nm23-H1的阳性表达率分别为66.7%(16/24)和50.0%(12/24),而在绝经后患者中两者的阳性表达率分别为77.8%(28/36)和77.8%(28/36).在绝经后患者中p53和nm23-H1基因的阳性表达与腋窝淋巴转移呈显著性相关(P=0.019和P=0.019).结论]p53可能参与绝经前妇女乳腺癌的发生,可能促进绝经后乳腺癌的转移;而nm23-H1可能参与绝经后乳腺癌的转移.

Expression of p53 and nm23-H1 in the Tissues of Breast Cancer and Its Correlation with Menopausal Status and Lymphatic Metastasis

Purpose] To study the role of expression of p53 and nm23-H1 in lymphatic metastasis of breast cancer,and the correlation between expression of p53 and nm23-H1.Methods] Expression of p53 and nm23-H1 in 60 patients with breast cancer was detected by immunohistochemical S-P method.Results] Of 60 cases with breast cancer,44 cases(73.3%)and 40 cases(66.7%)were positive for p53 and nm23-H1 protein respectively.In premenopausal patients with breast cancer,expression of p53 and nm23-H1 was 66.7% and 50.0% respectively,and in postmenopausal that was 77.8% and 77.8% respectively.In postmenopausal patients with breast cancer,expression of p53 and nm23-H1 was related to lymphatic metastasis(P=0.019 and P=0.019).Conclusion] p53 may play an role in the carcinogenesis of breast cancer in premenopausal patients by the regulation of endocrine system,and could promote lymphatic metastasis in postmenopausal breast cancer patients.nm23-H1 gene may take part in lymphatic metastasis in postmenopausal breast cancer patients.