Sympathetic control of substance P releasing enteric neurones in the guinea pig ileum |
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| Authors: | L Barthó P Holzer F Lembeck |
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| Institution: | 1. Department of Pharmacology, University Medical School Pécs, H-7643 Pécs Hungary;2. Department of Experimental and Clinical Pharmacology, University of Graz, Universitätsplatz 4, A-8010 Graz Austria |
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| Abstract: | The contractile response of the isolated guinea-pig ileum to cholecystokinin octapeptide (CCK-8) that remained in the presence of atropine was greatly inhibited by the substance P antagonist D-Pro2,D-Trp7,9-substance P. This indicates that the atropine-resistant contraction to CCK-8 is mediated by the release of substance P from enteric neurones. Activation of alpha-adrenergic receptors by noradrenaline, clonidine or mesenteric sympathetic nerve stimulation inhibited the atropine-resistant contraction to CCK-8 but did not affect the contractile effect of substance P. It is concluded that alpha-adrenergic receptors exert an inhibitory influence on the release of substance P from enteric neurones. |
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| Keywords: | substance P neurones guinea-pig ileum α-adrenergic agonists sympathetic stimulation Author for correspondence at: Department of Experimental and Clinical Pharmacology University of Graz Universitätsplatz 4 A-8010 Graz Austria |
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