Studies on Absorption and Tansport of Limoninoids from Fructus Evodiae in Caco-2 Cell Monolayer Model |
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| Authors: | YANG Xiu-wei TENG Jie ZHAO Bo ZHANG Lian-xue |
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| Affiliation: | 1. State Key Laboratory of Natural and Biomimetic Drugs Peking University,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China
2. College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China |
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| Abstract: | Objective To study the intestinal absorption and transepithelial transport of three limoninoids: evodol (EVO), limonin (LIM), and shihulimonin A (SHIA), isolated from Fructus Evodiae [the unripe fruit of Evodia rutaecarpa and Evodia rutaecarpa var. bodinieri] in the human intestine. Methods The in vitro cultured human colon carcinoma cell line, Caco-2 cell monolayer model, was applied to studying the absorption and transepithelial transport of the three limoninoids from apical (AP) to basolateral (BL) side ... |
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| Keywords: | absorption and transport apparent permeability coefficients Caco-2 cell limoninoids |
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