不同剂量阿司匹林对血小板功能的作用及临床意义

不稳定性心绞痛 (UA)和急性心肌梗死 (AMI)发病 ,尤其是溶栓前尽速抑制血小板功能有利于病情的控制 ,为此探索国人使用血小板抑制剂的起效时间及合理的用药剂量有重要的临床意义。本文应用不同剂量阿司匹林观察其抑制血小板的起效时间并探讨其临床意义。材料与方法对象1999年 4月 - 2 0 0 0年 10月的 40例可疑冠心病(coronaryheartdisease,CHD)或可疑冠心病稳定性心绞痛和心律失常但无器质性心脏病的住院病人 ,年龄 18- 65岁 ,两周内未服用阿司匹林或影响血小板功能的药物 ,如噻氯匹定 ,潘生丁 ,消炎痛等抗凝剂及抗纤溶剂。凡有出血倾向…

The Effect of Different Doses of Aspirin on Platelet Function and Its Clinical Importance

The aim of this study was to investigate the initial time of platelet inhibiting effect of aspirin (ASA) and the effects of different doses on equilibrium of prostacyclin(PGI 2)-thromboxane B 2(TXB 2). The effects of 100 mg and 300 mg ASA on Platelet count, platelet aggregation rate, TXB 2 and PGI 2 were investigated using cross-compare way for 40 aspirin ingestion patients. The results showed that the platelet counts decreased to 33% after 30 minutes of single-dose ASA ingestion of 100 mg and to 25.6% after 60 minutes. TXB 2 and PGI 2 also decreased meanwhile. The platelet counts decreased to 39.5%, 35.5% and 26.6%, respectively with dose of 300 mg on day 1, 2 and 3. The platelet counts decreased to 38.1% and 39.5%, respectively, after 120 minutes with 100 and 300 mg ASA ingestion, without significent difference. In conclusion ASA begins to inhibit platelet function after 30 minutes of ingestion, and gives the strongest inhibition after 60 minutes. Continuous ASA ingestion accumulates the inhibitory effect. The single-dose ASA ingestion of 100 and 300 mg have nearly the same inhibitory effects.