NOx (nitrite/nitrate) in cerebral spinal fluids obtained from patients with influenza-associated encephalopathy |
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Authors: | Kawashima H Watanabe Y Morishima T Togashi T Yamada N Kashiwagi Y Takekuma K Hoshika A Mori T |
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Affiliation: | Department of Paediatrics, Tokyo Medical University, Tokyo, Japan. hisashi@tokyo-med.ac.jp |
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Abstract: | It has become evident that the number of patients with a new type of influenza-associated encephalopathy is increasing in Japan. Nitric oxide (NO), a simple free radical gas, elicits a wide range of physiological and pathophysiological effects. We measured the nitrite/nitrate (NO x ) levels in cerebral spinal fluid obtained from patients with influenza-associated encephalopathy in order to evaluate the correlation between the NO production and the process of influenza-associated encephalopathy. Fifteen children were enrolled, aged from 1 to 9 years. As control we used 14 cerebral spinal fluids obtained from patients with urinary tract infection, respiratory infection or mumps meningitis without any sequela. NO 3 in influenza-associated encephalopathy was significantly higher than that of control group. On the other hand NO 2 was not significantly higher than that of control group. In particular, 4 out of 5 fatal cases revealed high NO 2 or NO 3. One case having normal levels in NO 2 and NO 3 showed that NH 3 was high. These results revealed that NO plays a role in influenza-associated encephalopathy through indirect effects of NO. |
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