Survivin、PKA在上皮性卵巢癌组织中的表达及意义

目的探讨Survivin、蛋白激酶A（PKA）在上皮性卵巢癌组织中的表达及其与临床相关指标之间的联系。方法 48例上皮性卵巢癌组织（卵巢癌组）采用免疫组织化学SP法测定Survivin、PKA的表达强度,结合临床指标进行分析,43例上皮性卵巢良性肿瘤作为对照组。结果 Survivin在上皮性卵巢良性肿瘤组织中的阳性表达率为14.0%（6/43）,在上皮性卵巢癌组织中的阳性表达率为83.3%（40/48）;PKA在上皮性卵巢良性肿瘤组织中的阳性表达率为90.7%（39/43）,在上皮性卵巢癌组织中的阳性表达率为52.1%（25/48）,两组比较,差异有统计学意义（P〈0.01）。不同癌细胞分化程度及TNM临床分期Survivin和PKA的表达阳性率比较,差异有统计学意义（P〈0.01）。结论 Survivin在上皮性卵巢癌组织中呈高表达,PKA在上皮性卵巢癌组织中呈低表达,且与临床指标相关,提示两者不仅参与了上皮性卵巢癌的发生,且可能与肿瘤的恶性进展有关。

Expression and significance of Survivin and PKA in epithelial ovarian cancer tissues

Objective To investigate the expression of Survivin and PKA in epithelial ovarian cancer tissue and corre- lation with clinical relevant indicators. Methods Expression intensity of Survivin and PKA were detected by SP method of immunohistochemistry in 48 cases of epithelial ovarian cancer tissues（the ovarian cancer group）,the relation- ship between clinical indicators and Survivin and PKA expressions were also analysed.The 43 cases with benign ep- ithelial ovarian tumor were taken as the control group. Results The positive expression rate of Survivion was 14.0% （6/ 43） in benign epithelial ovarian tumor and 83.3%（40/48） in epithelial ovarian cancer tissues respectively;the positive expression rate of PKA was 90.7%（39/43） in benign epithelial ovarian tumor and 52.1%（25/48） in epithelial ovarian cancer tissues respectively, there was a statistical diferrence between the two groups （P〈0.01）.Positive expression rate of Survivin and PKA was discrepant evidently in the TNM clinic stages and different degree of cancer cell differentiation. Conclusions There was a high expression of Survivin and low expression of PKA in epithelial ovarian cancer tissues and the expression relates to clinical indicators.It suggested both not only involved in epithelial ovarian cancer, might be related to the malignant progression of tumors.