慢性阻塞性肺疾病患者C反应蛋白测定及其临床意义

目的对慢性阻塞性肺疾病（COPD）患者进行C反应蛋白（CRP）测定,根据其不同时期的变化水平,分析其临床意义。方法将2010年1月～2012年1月来本院治疗的136例COPD患者进行分组,实验组42例为急性加重期COPD患者,对照组94例为缓解期COPD患者。分别测定两组患者的CRP及炎性细胞,如白细胞,中性粒细胞比值等。结果实验组：CRP测定平均值为（55.31±14.81）mg/L,对照组：CRP测定平均值为（7.2±4.0）mg/L,实验组明显高于对照组（t=29.3096,P〈0.01）;实验组CRP值的阳性率、白细胞和中性粒细胞比值的阳性率明显高于对照组（P〈0.01）。结论临床上通过测定CRP可以有效诊断COPD的严重程度,值得临床推广应用。

C-reactive protein determination and its clinical significance in patients with chronic obstructive pulmonary diseases

Objective To study the varied levels of C-reactive protein （CRP） at different stages in patients with chron- ic obstructive pulmonary disease （COPD） and analyze its clinical significance. Methods 136 patients with COPD pa- tients treated in our hospital from January 2010 to January 2012 were divided into the experimental group and the control group.In the experimental group,there were 42 patients with acute exacerbation of COPD,while in the control group,there were 94 COPD patients in remission stage.The CRP and inflammatory cells like white blood cell and neu trophil ratio etc were tested. Results In the experimental group,the mean value of CRP was （55.31±14.81） mg/L while in the control group,the mean value was （7.2±4.0） mg/L,The index in the former was remarkably higher than that in the latter （t=29.3096, P〈0.01）.The positive rate of CRP value,white blood cell and neutrophil ratio in the experimental group was significantly higher than the control group （P〈0.01）.Conclusion C-reactive protein determination is effective in the di- agnosis of COPD severity,it is worthy of clinical application.