| STAT-1 在膀胱癌组织中的表达及其临床意义 |
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| 引用本文： | 谢庆祥,林吓聪,张闽峰.STAT-1 在膀胱癌组织中的表达及其临床意义[J].肿瘤防治研究,2005,32(7):404-405. |
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| 作者姓名： | 谢庆祥 林吓聪 张闽峰 |
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| 作者单位： | 1. 363000,福建漳州,解放军第175医院泌尿外科
2. 363000,福建漳州,解放军第175医院病理科 |
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| 摘 要： | 目的 检测信号转导和转录激活因子-1(STAT-1)在膀胱癌组织中的表达，并探讨其在膀胱癌发病机制中作用及其临床意义。方法 应用免疫组织化学方法检测STAT-1在88例膀胱癌和12例正常膀胱组织中的表达。结果 膀胱癌中STAT-1表达阳性率为78．4％，显著高于正常膀胱组织的41．7％。STAT-1表达水平与膀胱癌病理分级、分期及复发之间密切相关。结论 STAT-1异常表达与膀胱癌的发生、发展关系密切，而且是肿瘤生物学行为较有价值的标记物。
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| 关 键 词： | 膀胱肿瘤 信号传导和转录激活因子 免疫组织化学 |
| 文章编号： | 1000-8578(2005)05-0404-02 |
| 收稿时间： | 2004-7-19 |
| 修稿时间： | 2004-9-29 |
The Significance of STAT-1 Expression in Bladder Cancer |
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| XIE Qing-xiang,LIN Xia-Zhong,ZHANG Ming-feng.The Significance of STAT-1 Expression in Bladder Cancer[J].Cancer Research on Prevention and Treatment,2005,32(7):404-405. |
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| Authors: | XIE Qing-xiang LIN Xia-Zhong ZHANG Ming-feng |
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| Affiliation: | 1. Department of Urology , The 175th Hospital of PLA , Zhangzhou , Fujiang 363000 , China; 2. Department of Pathology |
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| Abstract: | Objective This study was designed to investigate the role of STAT-1 in the pathogenesis of bladder cancer and its relationship with tumor biological behaviors. Methods The expression of STAT-1 in 88 cases of cancerous tissues and 12 cases of normal bladder tissues was determined by immunotistochemical staining. Results The protein expression rates of STAT-1 in bladder cancer and normal bladder tissues were 78.4% and 41.7%,respectively(P= 0.033). Expression of STAT-1 in bladder cancer was correlated with tumor grade, stage and recurrence (P= 0.043,P= 0.008 and P= 0.002). Conclusion Abnormality of STAT-1 may play an important role in the tumor genesis of bladder cancer. Determination of STAT-1 can be used to indicate the tumor biological behavior. |
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| Keywords: | Bladder neoplasms STAT Immunohistochemistry |
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