我院药品不良反应报告的回顾性分析

目的分析评价我院药品不良反应（ADR）呈报的基本情况和填报质量，为深入开展ADR监测工作及合理用药提供参考。方法从广东省ADR监测中心数据库下载我院上报且省中心已做出评价的ADR报告表，进行患者年龄、性别、药品类别、ADR过程描述、关联评价统计、分析。结果360份ADR报告涉及的药品有16类共98种药品，其中抗微生物药品31种和中药制剂13种，位居前列（依次为203例、28例）。ADR所累及的器官、系统主要为皮肤及其附件（63％），其次为消化系统（21％）。绝大多数ADR的转归良好。静脉给药导致的ADR例数为235例（65％）；新的、严重的不良反应上报较少；报告质量有待提高。结论应强化培训工作，增强ADR呈报意识和责任感，以提高ADR报告质量。

Analysis of adverse drug reaction reports

Objective To investigate the essential features of adverse drug reactions （ADR） in our hospital, assess the quality of ADR reports and provide information for ADR monitoring and rational drug use. Methods All reported ADR cases were downloaded from provincial center for ADR monitoring. Some data formats were converted or added necessarily. All items of the report form were collected and analyzed. Results 16 drug categories and total 98 kinds of medicines were involved in 360 ADR cases. 31 antimicrobials and 13 Chinese herbal preparations, which led to 203 ADR cases and 28 ADR cases respectively, ranked first and second among all the drugs. The lesions of ADR involved primarily skin and its accessories（ 3% ） , then gastrointestinal system （21%）. The intravenous route of administration caused 235 ADR cases （65%）. New and severe ADR reports are few. The qualities of most reports were poor. Conclusion The training program for ADR reporters and cultivation of professional ability should be strengthened. ADR reporters＇ cognition and responsibility should be enhanced so as to improve the report quality.