新生儿胃肠功能障碍与凝血功能关系的研究

目的 探讨胃肠功能障碍新生儿凝血功能的变化及其临床意义.方法 研究组为40例胃肠功能障碍足月新生儿,按胃肠功能障碍诊断标准分为早、中、晚期三组,分别为12、19、9例.行血常规和凝血功能检查,并进行危重病例评分.同期纳入40例正常新生儿作为对照组.比较各组间凝血功能指标的差异,并评价胃肠功能障碍与危重病例评分的关系.结果 早期组凝血功能指标与对照组比较差异无统计学意义(P>0.05),中、晚期组与对照组比较差异有统计学意义(P<0.05):中期组与晚期组凝血功能指标比较差异亦有统计学意义(P<0.05);危重病例评分越低,胃肠功能障碍程度越重.结论 胃肠功能障碍的程度越重,凝血功能紊乱程度越重,危重病例评分越低.提示一旦发生胃肠功能障碍应提高警惕,密切监测凝血功能,做好早期干预.

The relationship between coagulation function and gastrointestinal dysfunction in neonate

Objective To investigate the changes of coagulation function in the neonates patients with gastrointestinal dysfunction and chnical significance. Methods Forty neonates with gastrointestinal dysfunction were included, which were divided into three groups according to diagnosis criterion of gastrointestinal dysfunction: early group, medium group and late group. Coagulation function was tested and neonatal critical illness score(NCIS) was done. Forty normal neonates were selected as control group. The difference of coagulation function among all groups was observed, and the relationship between coagulation function and NCIS were evaluated. Results Compared with control group, the indexs of coagulation function of early group was no statistical difference (P>0.05), however the result between medium group and late group was significantly difference (P<0.05). The difference of coagulation function between medium group and late group was also significant (P<0.05), the lower NCIS was, the more serious the gastrointestinal function was. Conclusions The more serious the gastrointestinal dysfunction is, the poorer the coagulation function is and the lower the NCIS is, which suggest coagulation function should be monitored in neonates with gastrointestinal dysfunction, and early intervention should be done accordingly.