The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients |
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Authors: | Colle Jean-Hervé Moreau Jean-Louis Fontanet Arnaud Lambotte Olivier Delfraissy Jean-François Thèze Jacques |
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Affiliation: | Unité Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France. |
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Abstract: | Measurements of Bcl-2 and CD25 expression suggested that IL-7R function is modified in CD4 lymphocytes of untreated viraemic patients. The extent of IL-7R function restoration post-HAART was analysed. A positive linear relationship was demonstrated between IL-7Ralpha expression and the magnitude of IL-7-induced responses in healthy individuals, whereas this relationship is lost in HIV-infected patients, suggesting that viraemic patients suffer a receptor signaling transduction defect in IL-7R function. IL-7 responsiveness is only partly restored by HAART. |
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