Urinary biomarker of oxidative stress correlating with outcome in critically septic patients |
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Authors: | Wei-Erh Cheng Chuen-Ming Shih Liang-Wen Hang Kuen-Yuh Wu Hsin-Ling Yang Wu-Huei Hsu Te-Chun Hsia |
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Institution: | (1) Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, 2 Yuh-Der Rd., 404 Taichung, Taiwan;(2) Division of Environmental Health and Occupational Medicine, National Health Research Institute, 35 Keyan Road, 350 Miaoli County, Zhunan Town, Miaoli County, Taiwan;(3) Department of Nutrition, China Medical University, 91 Hsueh-Shih Road, 404 Taichung, Taiwan |
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Abstract: | Objective To determine whether urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), an in vivo parameter of oxidative stress, is correlated
with the outcome of critically septic patients.
Design and setting Clinical outcome study in an adult medical ICU.
Patients Eighty-five consecutive septic patients: 59 men and 26 women.
Measurements and results Urinary 8-OHdG was analyzed using isotope-dilution liquid chromatography with tandem mass spectrometry (LC/MS/MS). ICU mortality
in these 85 septic patients was 25.9% (n = 22) and hospital mortality 38.8% (n = 33). APACHE II scores of survivors on day 1, on day 3, and the difference between them differed significantly from those
of nonsurvivors (day 1, 21.0 ± 7.1 vs. 25.9 ± 8.0; day 3, 15.0 ± 5.8 vs. 23.2 ± 8.3; difference, 6.0 ± 5.5 vs. 1.7 ± 6.6).
Urinary 8-OHdG was significantly lower in survivors than in nonsurvivors on day 1 (1.8 ± 2.4 vs. 3.0 ± 2.4). The area under
receiver operating characteristic curve analysis for the association between day 1 urinary 8-OHdG and ICU mortality was 0.71.
The comparison performed upon discharge from hospital revealed similar results.
Conclusions This is a preliminary study. The excretion of the urinary 8-OHdG, as measured using isotope-dilution LC/MS/MS, as the APACHE
II score, were correlated with the outcome of critically septic patients in medical ICU.
An erratum to this article can be found at |
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Keywords: | Sepsis Oxidative stress 8-hydroxy-2′ -deoxyguanosine Acute Physiology and Chronic Health Evaluation II Outcome assessment |
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