逍遥枣仁汤联合舍曲林治疗抑郁症患者对照研究 |
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引用本文: | 王军峰.逍遥枣仁汤联合舍曲林治疗抑郁症患者对照研究[J].中医临床研究,2014(14):15-17. |
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作者姓名: | 王军峰 |
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作者单位: | 许昌建安医院; |
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摘 要: | 目的:探讨逍遥枣仁汤联合舍曲林治疗抑郁症的临床疗效和安全性。方法:将72例抑郁症患者随机分为逍遥枣仁汤联合舍曲林组36例和单用舍曲林组36例,采用汉密尔顿抑郁量表(HAMD)和治疗中出现的症状量表(TESS)于治疗前和治疗后1、2、4、8周分别评定疗效和不良反应。结果:从治疗第一周末起各时点,两组HAMD评分及减分率的差异有统计学意义(P〈0.05或 P〈0.01)。逍遥枣仁汤联合舍曲林组的有效率为91.67%,舍曲林组的有效率为80.56%。两组间差异有统计学意义(P〈0.05)。两组 TESS 评分及减分率的差异有统计学意义(P〈0.05)。结论:逍遥枣仁汤联合舍曲林对抑郁症的疗效优于单用舍曲林组,且起效快,不良反应轻微。
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关 键 词: | 逍遥枣仁汤 舍曲林 抑郁症 |
A clinical study on treating depression with Xiaoyao Zaoren decoction plus sertraline |
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Abstract: | Objective: To explore clinical efficacy and safety of Xiaoyao Zaoren decoction plus sertraline on treating depression. Methods: 78 patients were randomly divided into two groups: Xiaoyao Zaoren decoction plus sertraline (n=36) and sertraline solo (n=36). The hamilton depression scale (HAMD) and treatment emergent symptom scale (TESS) were adopted to evaluate the effcacy and adverse reactions at baseline and after 1, 2, 4 and 8 weeks treatment. Results: There were significant differences on the scores of HAMD and reducing score rate between two groups (P〈0.05 orP〈0.01). The efficiency in Xiaoyao Zaoren decoction plus sertraline group was 91.67%, in the sertraline group it was 80.56%, the difference was statistically significant (P〈0.05). There were significant differences on the scoresof TESS and between two groups (P〈0.05). Conclusion: Xaoyao Zaoren decoction plus sertraline has better effects, quick effective, with fewer adverse events. |
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Keywords: | Xiaoyao Zaoren decoction Sertraline Depression |
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