| 利巴韦林缓释片的制备及其释放度测定 |
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| 引用本文： | 杨伟俊,罗玉琴,邢建国,于富生,戴秀勇. 利巴韦林缓释片的制备及其释放度测定[J]. 中国医院药学杂志, 2005, 25(7): 628-631 |
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| 作者姓名： | 杨伟俊 罗玉琴 邢建国 于富生 戴秀勇 |
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| 作者单位： | 1. 新疆药物研究所,新疆,乌鲁木齐,830002
2. 新疆华世丹药物研究有限公司,新疆,乌鲁木齐,830011 |
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| 摘 要： | 目的:制备利巴韦林缓释片,对其释放机制进行考察.方法:建立高效液相色谱(HPLC)体外释放度测定法,以羟丙基甲基纤维素(HPMC)为主要辅料,制备亲水凝胶型骨架片,采用单因素试验筛选辅料种类,通过均匀设计优化出缓释片的处方.结果:所制备的缓释片在8 h内呈良好的零级释药特征.结论:以均匀设计优选的利巴韦林缓释片处方合理,体外释放性能良好.
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| 关 键 词： | 利巴韦林 缓释片 释放度 均匀设计 |
| 文章编号： | 1001-5213(2005)07-0628-04 |
| 收稿时间： | 2004-07-27 |
| 修稿时间： | 2004-07-27 |
Preparation of ribavrin sustained release tablets and its drug release |
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| YANG Wei-jun,LUO Yu-qin,XING Jian-guo,YU Fu-sheng,DAI Xiu-yong. Preparation of ribavrin sustained release tablets and its drug release[J]. Chinese Journal of Hospital Pharmacy, 2005, 25(7): 628-631 |
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| Authors: | YANG Wei-jun LUO Yu-qin XING Jian-guo YU Fu-sheng DAI Xiu-yong |
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| Abstract: | OBJECTIVE To prepare ribavirin sustained release tablets and investigate its release mechanism in vitro. METHODS To establish a HPLC method for determing the content of ribavirin. The water-soluble matrix tablet was preparaed by use of HPMC.The optimal formulation was obtained by uniform design. RESULTS The release profile of the tablets in vitro was fitted well by zeros-order release within 8 hours. CONCLUSION The formulation and the release mechanism in vitro is reasonable. |
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| Keywords: | ribavirin sustained release tablet drug release uniform design |
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