Prognostic significance and clinical relevance of the expression of the HER family of type I receptor tyrosine kinases in human laryngeal squamous cell carcinoma |
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| Authors: | Giovanni Almadori Francesco Bussu Marco Gessi Gabriella Ferrandina Giovanni Scambia Libero Lauriola Gaetano Paludetti Franco O. Ranelletti |
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| Affiliation: | 1. Dept. of Otolaringology, Università Cattolica del S. Cuore, Rome, Italy;2. Div. of Neuropathology, Fondazione IRCCS Istituto “C.Besta”, Milan, Italy;3. Dept. of Gynecology, Università Cattolica del S. Cuore, Rome, Italy;4. Dept. of Pathology, Università Cattolica del S. Cuore, Rome, Italy;5. Dept. of Histology, Università Cattolica del S. Cuore, Rome, Italy;1. Department of Mental Health and Public Medicine, Second University of Naples, Italy;2. Internal Medicine and Hepatology, Second University of Naples, Italy;3. Department of Experimental Medicine, Second University of Naples, Italy;4. Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy;5. Department of Woman, Child and of General and Specialized Surgery, Second University of Naples, Italy;6. Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy;2. Duke Cancer Institute, Durham, North Carolina;3. Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Canada;2. Advanced Optical Microscopy Facility, University Health Network, Toronto, ON, Canada;3. Division of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada;1. Miami University, Department of Zoology, 212 Pearson Hall, Oxford 45056, Ohio;2. GEI Consultants, Inc. , 4601 DTC Blvd, Suite 900, Denver 80237, Colorado;1. Institute of Animal Physiology, Slovak Academy of Sciences, Ko?ice, Slovakia;2. Institute of Neurobiology, Slovak Academy of Sciences, Ko?ice, Slovakia;1. Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA;2. Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA |
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| Abstract: | IntroductionThe full clinical relevance of the expression pattern of HER family of type I receptor tyrosine kinases in laryngeal squamous cell carcinoma remains to be elucidated. We evaluated the clinical relevance of such parameter in our population.Patients and methodsThis study examined the expression pattern of HER family receptor members by quantitative immunohistochemistry and the amount of the EGF binding sites by a radioligand binding assay, in the same group of 67 LSCC patients, analysing the correlation between the expression of the four HER receptors and the clinical and prognostic parameters.ResultsHER1 levels inversely correlated with that of HER2–4, while HER2–4 directly correlated among them. Cox univariate analysis using HER1–4 values as continuous covariates indicated that HER1 expression was directly associated with the risk of death and relapse while that of HER2–4 was inversely associated with the risk of death. Among the patients with high HER1 expressing tumours, those with tumours co-expressing HER2–4 showed a lower risk of death and relapse (in particular regional relapse) than those with tumours displaying a negative HER2–4 status.ConclusionsThe evaluation of HER2–4 status adds more power to the prognostic role of HER1 detection. In the era of molecularly targeted therapy, the expression of HER family of receptor tyrosine kinases in LSCC may hold relevant clinical significance and turn out to be a key factor in prognostic assessment and in treatment planning. |
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