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Amplification of epidermal growth factor receptor gene in renal cell carcinoma
Authors:Iman El-Hariry  Thomas Powles  Mike R Lau  Cora N Sternberg  Alain Ravaud  Hans von der Maase  Niko Zantl  Peter Harper  Frédéric Rolland  Bruno Audhuy  Friederike Barthel  Jean-Pascal Machiels  Pina Patel  Ernst-Dietrick Kreuser  Robert E Hawkins
Institution:1. Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan;2. Department of Clinical Oncology, Aichi Cancer Center Hospital, Aichi, Japan;3. Division of Gastroenterology, Saitama Cancer Center, Saitama, Japan;4. Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center, Ehime, Japan;5. Division of Gastroenterology, Chiba Cancer Center, Chiba, Japan;6. Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka, Japan;7. Division of Translational Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba, Japan;8. Division of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan;9. Clinical Trial Promotion Department, Chiba Cancer Center, Chiba, Japan
Abstract:Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.
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