左心室心肌功能参数评估2型糖尿病患者血清补体C3水平

目的 观察左心室心肌功能参数评估2型糖尿病(T2DM)患者血清补体C3水平的价值。方法 纳入38例T2DM患者，按C3水平将其分为低C3(C3^-组，n=19)和高C3组(C3⁺组，n=19),另以61例无糖尿病及心脑血管病史的甲状腺结节或乳腺结节患者为对照组；比较3组实验室指标、舒张末期室间隔厚度(IVSD)、舒张末期左心室后壁厚度(LVPWD)、舒张末期左心室内径(LVEDD)、收缩末期左心室内径(LVESD)、左心室射血分数(LVEF)、左心室心内膜下心肌整体圆周应变(GCS_endo)、中层心肌整体圆周应变(GCS_mid)及心外膜下心肌整体圆周应变(GCS_epi),分析GCS_endo、GCS_mid、GCS_epi与实验室指标的相关性，观察以之评估患者血清补体C3水平的价值。结果 空腹血糖、糖化血红蛋白、单核细胞、中性粒细胞百分比、淋巴细胞百分比、嗜酸性粒细胞百分比、嗜碱性粒细胞百分比、补体C3水平、LVESD、...

Left ventricular myocardial function parameters for diagnosis of serum complement C3 level in patients with type 2 diabetes mellitus

Objective To explore the value of left ventricular myocardial function parameters for evaluating serum complement C3 level in patients with type 2 diabetes mellitus (T2DM). Methods Thirty-eight T2DM patients were enrolled and divided into low (C3^- group, n=19) and high C3 group (C3⁺ group, n=19) according to C3 level, and 61 patients with thyroid nodules or breast nodules without history of diabetes, cardiovascular nor cerebrovascular diseases were taken as controls(control group). The laboratory indexes, interventricular septal thickness at diastole (IVSD), left ventricular posterior wall diameter at diastole (LVPWD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), endocardial myocardial global circumferential strain (GCS_endo), mid-myocardial global circumferential strain (GCS_mid) and epicardial myocardial global circumferential strain (GCS_epi) were compared among 3 groups. The correlations of GCS_endo, GCS_mid, GCS_epi and laboratory indexes were observed, and their values for evaluating serum complement C3 level were analyzed. Results There were significant differences of fasting blood glucose, glycosylated hemoglobin, monocyte, neutrophil percentage, lymphocyte percentage, eosinophil percentage, basophil percentage, complement C3 level, LVESD, IVSD, E/e, e/a, GCS_endo, GCS_mid and GCS_epi among 3 groups (all P<0.05). GCS_endo, GCS_mid and GCS_epi were positively correlated with fasting blood glucose (r=0.198, 0.185, 0.214, all P<0.05) and glycosylated hemoglobin (r=0.236, 0.202, 0.249, all P<0.05), but negatively correlated with neutrophil percentage (r=-0.162, -0.162, -0.165, all P<0.05). Partial correlation analysis of fasting blood glucose control showed that GCS_endo, GCS_mid and GCS_epi were not significantly correlated with glycosylated hemoglobin and neutrophil percentage (all P>0.05). The area under the curve (AUC) of GCS_endo, GCS_mid and GCS_epi for evaluating complement C3 level in T2DM patients was 0.754, 0.710 and 0.707, respectively, and the AUC of GCS_endo was higher than that of GCS_mid and GCS_epi (both P<0.05). Conclusion GCS_endo could be used for evaluating serum complement C3 level in T2DM patients.