熊去氧胆酸联合甘草甜素片治疗妊娠期肝内胆汁淤积症的临床疗效观察

目的探讨熊去氧胆酸联合甘草甜素片治疗妊娠期肝内胆汁淤积症(ICP)的临床疗效。方法 128例ICP患者随机分为两组各64例,对照组给予熊去氧胆酸治疗,观察组给予熊去氧胆酸联合甘草甜素片治疗,比较两组的治疗效果。结果治疗后,观察组的瘙痒评分显著低于对照组,肝功能指标TBA、 ALT、 AST水平均显著低于对照组,不良妊娠结局总发生率显著低于对照组(P <0.05)。结论熊去氧胆酸联合甘草甜素片可显著改善ICP患者的瘙痒症状和肝功能,有效降低不良妊娠结局发生率。

Observation on the Clinical Efficacy of Ursodeoxycholic Acid Combined with Glycyrrhizin Tablet in the Treatment of IntrahepaticCholestasis of Pregnancy

Objective To explore the clinical efficacy of ursodeoxycholic acid combined with glycyrrhizin tablet in the treatment of intrahepatic cholestasis of pregnancy(ICP).Methods 128 cases of ICP patients were randomly divided into two groups,with 64 cases in each group.The control group was treated with ursodeoxycholic acid,and the observation group was treated with ursodeoxycholic acid combined with glycyrrhizin tablet.The curative effects of two groups were compared.Results After treatment,the pruritus score of observation group was significantly lower than that of control group,the levels of liver function indicators including TBA,ALT and AST were significantly lower than those of control group,and the total incidence of adverse pregnancy outcomes was significantly lower than that of control group(P<0.05).Conclusions Ursodeoxycholic acid combined with glycyrrhizin tablet can obviously improve the pruritus symptom and liver function of ICP patients,and effectively reduce the incidence of adverse pregnancy outcomes.