Body height and sex-related differences in incidence of venous thromboembolism: A Danish follow-up study |
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| Authors: | Marianne Tang Severinsen Søren Paaske Johnsen Anne Tjønneland Kim Overvad Claus Dethlefsen Søren Risom Kristensen |
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| Institution: | 1. Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg and Aarhus, Denmark;2. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;3. Department of Cardiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark;4. Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark;5. Department of Clinical Biochemistry, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark;1. Department of Information & Communication Engineering, Hohai University and Changzhou Key Lab. of Photovoltaic System Integration and Production Equipment Technology, Changzhou, China;2. Guangdong Provincial Key Lab. of Petrochemical Equipment Fault Diagnosis, Guangdong University of Petrochemical Technology, China;1. Center for Outcomes Research, Department of Surgery, University of Massachusetts Medical School, Worcester;2. Department of Quantitative Health Science, University of Massachusetts Medical School, Worcester;3. Department of Medicine, McMaster University, Hamilton, Ontario, Canada;1. Department of Medicine, University of Alberta, Edmonton, Canada;2. School of Public Health, University of Alberta, Edmonton, Canada |
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| Abstract: | BackgroundSex-related differences in incidence rate of venous thromboembolism (VTE) have been reported. It is unclear whether these differences reflect sex-related differences in the incidence of deep venous thrombosis (DVT), pulmonary embolism (PE) or both and to which extent the differences are mediated by known risk factors for VTE.ObjectiveTo compare the incidence of DVT and PE between middle-aged men and women.MethodsWe computed sex-specific incidences of VTE, DVT and PE and estimated the crude and adjusted incidence rate ratios (IRR) of VTE, DVT and PE using Cox regression for men versus women participating in the prospective study Diet, Cancer and Health. We controlled for body mass index, body height, leisure-time physical activity and smoking dose.ResultsWe verified 641 VTE events during a median follow-up time of 10 years. The overall incidence of VTE was 1.15 95%CI: 1.07–1.25] per thousand person years; it was higher for men than women (crude IRR: 1.55 95%CI: 1.32–1.82]). The adjusted IRR for DVT was 1.06 95%CI: 0.75–1.50] and for PE 0.60 95%CI: 0.41–1.18] for men versus women. The higher rate among men appeared to be mediated mainly by body height.ConclusionsIn this middle-aged population, men experienced a higher incidence of VTE due to a higher incidence of DVT. The higher incidence among men appeared to be mediated by body height. Adjusted for body height, male sex was not associated with an excess risk of either VTE or DVT but the risk of PE was notably lower compared with women. |
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