CD4+ and CD56+ acute monoblastic leukemia. |
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| Authors: | T Tauchi K Ohyashiki J H Ohyashiki Y Kawanishi Y Kimura M Saito S Nakazawa Y Kawai K Toyama |
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| Institution: | First Department of Internal Medicine, Tokyo Medical College, Japan. |
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| Abstract: | We report here a patient with acute monoblastic leukemia whose leukemia cells had CD4 (T4) and CD56 (NKH-1) antigens, in addition to CD36 (OKM5) antigen. The leukemia cells did not have NK or ADCC activities. They showed no rearrangements of immunoglobulin heavy (IgH) chain and T cell receptor (TCR)-beta chain genes, indicating that the leukemia cells were nonlymphoid. The presence of this case suggests that leukemia cells could be originated from monocytes with NK-associated antigen without IgH or TCR rearrangements. |
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| Keywords: | acute monoblastic leukemia CD4 antigen CD56 antigen |
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